biostudies-literatureUnknown6Wang HThe main purpose of this study was to compare the antioxidant and anticancer activities of lycopene samples with different ratios of Z-isomers. Lycopene samples containing 5%, 30%, and 55% Z-isomers were successfully prepared by using thermal treatment combined with anti-solvent crystallization. The <i>in vitro</i> bio-accessibility of lycopene was estimated by the determination of partition factor (PF) and the results showed that lycopene with 55% Z-isomers possessed the highest bio-accessibility. Moreover, DPPH and ABTS assays suggested that the antioxidant activity of lycopene increased with the Z-isomers content from 5% to 55%. However, lycopene inhibited the survival of human hepatocellular carcinoma cells (HepG2) in a dose and time-dependent manner. The highest inhibition of HepG2 ceCurrent research in food science100455https://www.ebi.ac.uk/biostudies/studies/S-EPMC9929522biostudies-literatureAntioxidant, anticancer activity and molecular docking study of lycopene with different ratios of Z-isomers.PMC9929522Zhang WHui AWu ZZhou ALiu QBian HLin YWang HfalseAntioxidant, anticancer activity and molecular docking study of lycopene with different ratios of Z-isomers.The main purpose of this study was to compare the antioxidant and anticancer activities of lycopene samples with different ratios of Z-isomers. Lycopene samples containing 5%, 30%, and 55% Z-isomers were successfully prepared by using thermal treatment combined with anti-solvent crystallization. The <i>in vitro</i> bio-accessibility of lycopene was estimated by the determination of partition factor (PF) and the results showed that lycopene with 55% Z-isomers possessed the highest bio-accessibility. Moreover, DPPH and ABTS assays suggested that the antioxidant activity of lycopene increased with the Z-isomers content from 5% to 55%. However, lycopene inhibited the survival of human hepatocellular carcinoma cells (HepG2) in a dose and time-dependent manner. The highest inhibition of HepG2 ce2023-01-01T00:00:00Z20232025-05-31T23:51:57.734Z2024-11-12T12:57:54.765ZS-EPMC99295223681599710.1016/j.crfs.2023.100455