{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["He L"],"funding":["NICHD NIH HHS","Howard Hughes Medical Institute","NIMH NIH HHS","NINDS NIH HHS"],"pagination":["1689-1699.e6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9930308"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["110(10)"],"pubmed_abstract":["Successful recall of a contextual memory requires reactivating ensembles of hippocampal cells that were allocated during memory formation. Altering the ratio of excitation-to-inhibition (E/I) during memory retrieval can bias cell participation in an ensemble and hinder memory recall. In the case of Rett syndrome (RTT), a neurological disorder with severe learning and memory deficits, the E/I balance is altered, but the source of this imbalance is unknown. Using in vivo imaging during an associative memory task, we show that during long-term memory retrieval, RTT CA1 cells poorly distinguish mnemonic context and form larger ensembles than wild-type mouse cells. Simultaneous multiple whole-cell recordings revealed that mutant somatostatin expressing interneurons (SOM) are poorly recruited by"],"journal":["Neuron"],"pubmed_title":["A weakened recurrent circuit in the hippocampus of Rett syndrome mice disrupts long-term memory representations."],"pmcid":["PMC9930308"],"funding_grant_id":["R01 NS100738","R01 NS057819","R01 MH120404","R01 NS110767","P50 HD103555","R56 NS100738","R01 MH122169"],"pubmed_authors":["Tang J","Jing J","Zoghbi HY","Caudill MS","Jiang X","Wang W","He L","Sun Y"],"additional_accession":[]},"is_claimable":false,"name":"A weakened recurrent circuit in the hippocampus of Rett syndrome mice disrupts long-term memory representations.","description":"Successful recall of a contextual memory requires reactivating ensembles of hippocampal cells that were allocated during memory formation. Altering the ratio of excitation-to-inhibition (E/I) during memory retrieval can bias cell participation in an ensemble and hinder memory recall. In the case of Rett syndrome (RTT), a neurological disorder with severe learning and memory deficits, the E/I balance is altered, but the source of this imbalance is unknown. Using in vivo imaging during an associative memory task, we show that during long-term memory retrieval, RTT CA1 cells poorly distinguish mnemonic context and form larger ensembles than wild-type mouse cells. Simultaneous multiple whole-cell recordings revealed that mutant somatostatin expressing interneurons (SOM) are poorly recruited by","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-29T13:58:59.885Z","creation":"2025-02-19T03:25:54.828Z"},"accession":"S-EPMC9930308","cross_references":{"pubmed":["35290792"],"doi":["10.1016/j.neuron.2022.02.014"]}}