{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Meng F"],"funding":["Chongqing Science and Technology Bureau, China"],"pagination":["553-562"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9930433"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(4)"],"pubmed_abstract":["Regulatory T cell (Treg) activity and differentiation in visceral adipose tissue (VAT) play an important role in inhibiting chronic inflammation and insulin resistance. Whether JAZF-1 and PPAR-γ mediate VAT Treg differentiation to promote the inhibition of chronic inflammation and insulin resistance remains unclear. Here, we investigated the roles of JAZF-1 and PPAR-γ in VAT Treg differentiation, inflammation and insulin resistance using a transgenic mouse model. First, we determined that the levels of glucose and insulin biochemical markers in the JAZF-1 transgenic general feeding or high-fat groups were lower than those in the wild-type general feeding or high-fat groups. Second, the levels of CD4<sup>+</sup> , CD25<sup>+</sup> , and FOXP3<sup>+</sup> differentiation markers in the JAZF-"],"journal":["Journal of cellular and molecular medicine"],"pubmed_title":["Regulatory T cells differentiation in visceral adipose tissues contributes to insulin resistance by regulating JAZF-1/PPAR-γ pathway."],"pmcid":["PMC9930433"],"funding_grant_id":["cstc2019jcyj-msxmX0122"],"pubmed_authors":["Meng F","Hao P","Du H"],"additional_accession":[]},"is_claimable":false,"name":"Regulatory T cells differentiation in visceral adipose tissues contributes to insulin resistance by regulating JAZF-1/PPAR-γ pathway.","description":"Regulatory T cell (Treg) activity and differentiation in visceral adipose tissue (VAT) play an important role in inhibiting chronic inflammation and insulin resistance. Whether JAZF-1 and PPAR-γ mediate VAT Treg differentiation to promote the inhibition of chronic inflammation and insulin resistance remains unclear. Here, we investigated the roles of JAZF-1 and PPAR-γ in VAT Treg differentiation, inflammation and insulin resistance using a transgenic mouse model. First, we determined that the levels of glucose and insulin biochemical markers in the JAZF-1 transgenic general feeding or high-fat groups were lower than those in the wild-type general feeding or high-fat groups. Second, the levels of CD4<sup>+</sup> , CD25<sup>+</sup> , and FOXP3<sup>+</sup> differentiation markers in the JAZF-","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-18T13:38:04.303Z","creation":"2025-04-06T23:24:54.739Z"},"accession":"S-EPMC9930433","cross_references":{"pubmed":["36734198"],"doi":["10.1111/jcmm.17680"]}}