{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Deloney M"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","NCATS NIH HHS","National Center for Advancing Translational Sciences of the","NIAMS NIH HHS","National Institutes of Health, United States of America"],"pagination":["47-58"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9930616"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["323"],"pubmed_abstract":["Inflammation following joint trauma contributes to cartilage degradation and progression of post traumatic osteoarthritis (PTOA). Therefore, drug delivery vehicles that deliver effective anti-inflammatory treatments have the potential to prevent PTOA. We have developed solid and hollow, thermoresponsive nanoparticles for the controlled release of our anti-inflammatory MK2-inhibiting (MK2i) peptide for intra-articular injection to halt inflammation that contributes to the advancement of PTOA. This system exploits the thermosensitive characteristic of N-isopropyl acrylamide (NIPAm) to transition phases when passing through its lower critical solution temperature (LCST). The nanoparticles (NPs) swell below the LCST and constrict above it. Non-crosslinked poly(NIPAm) (pNIPAm), held above its L"],"journal":["Journal of controlled release : official journal of the Controlled Release Society"],"pubmed_title":["Thermoresponsive, hollow, degradable core-shell nanoparticles for intra-articular delivery of anti-inflammatory peptide."],"pmcid":["PMC9930616"],"funding_grant_id":["R01AR065398","UL1 TR001860","TL1 TR001861","R01 AR065398"],"pubmed_authors":["Smart K","Deloney M","Christiansen BA","Panitch A"],"additional_accession":[]},"is_claimable":false,"name":"Thermoresponsive, hollow, degradable core-shell nanoparticles for intra-articular delivery of anti-inflammatory peptide.","description":"Inflammation following joint trauma contributes to cartilage degradation and progression of post traumatic osteoarthritis (PTOA). Therefore, drug delivery vehicles that deliver effective anti-inflammatory treatments have the potential to prevent PTOA. We have developed solid and hollow, thermoresponsive nanoparticles for the controlled release of our anti-inflammatory MK2-inhibiting (MK2i) peptide for intra-articular injection to halt inflammation that contributes to the advancement of PTOA. This system exploits the thermosensitive characteristic of N-isopropyl acrylamide (NIPAm) to transition phases when passing through its lower critical solution temperature (LCST). The nanoparticles (NPs) swell below the LCST and constrict above it. Non-crosslinked poly(NIPAm) (pNIPAm), held above its L","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2026-03-17T15:44:56.263Z","creation":"2025-04-04T11:16:53.61Z"},"accession":"S-EPMC9930616","cross_references":{"pubmed":["32278830"],"doi":["10.1016/j.jconrel.2020.04.007"]}}