biostudies-literatureDeloney MNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNCATS NIH HHSNational Center for Advancing Translational Sciences of theNIAMS NIH HHSNational Institutes of Health, United States of America47-58https://www.ebi.ac.uk/biostudies/studies/S-EPMC9930616biostudies-literatureUnknown323Inflammation following joint trauma contributes to cartilage degradation and progression of post traumatic osteoarthritis (PTOA). Therefore, drug delivery vehicles that deliver effective anti-inflammatory treatments have the potential to prevent PTOA. We have developed solid and hollow, thermoresponsive nanoparticles for the controlled release of our anti-inflammatory MK2-inhibiting (MK2i) peptide for intra-articular injection to halt inflammation that contributes to the advancement of PTOA. This system exploits the thermosensitive characteristic of N-isopropyl acrylamide (NIPAm) to transition phases when passing through its lower critical solution temperature (LCST). The nanoparticles (NPs) swell below the LCST and constrict above it. Non-crosslinked poly(NIPAm) (pNIPAm), held above its LJournal of controlled release : official journal of the Controlled Release SocietyThermoresponsive, hollow, degradable core-shell nanoparticles for intra-articular delivery of anti-inflammatory peptide.PMC9930616R01AR065398UL1 TR001860TL1 TR001861R01 AR065398Smart KDeloney MChristiansen BAPanitch AfalseThermoresponsive, hollow, degradable core-shell nanoparticles for intra-articular delivery of anti-inflammatory peptide.Inflammation following joint trauma contributes to cartilage degradation and progression of post traumatic osteoarthritis (PTOA). Therefore, drug delivery vehicles that deliver effective anti-inflammatory treatments have the potential to prevent PTOA. We have developed solid and hollow, thermoresponsive nanoparticles for the controlled release of our anti-inflammatory MK2-inhibiting (MK2i) peptide for intra-articular injection to halt inflammation that contributes to the advancement of PTOA. This system exploits the thermosensitive characteristic of N-isopropyl acrylamide (NIPAm) to transition phases when passing through its lower critical solution temperature (LCST). The nanoparticles (NPs) swell below the LCST and constrict above it. Non-crosslinked poly(NIPAm) (pNIPAm), held above its L2020-01-01T00:00:00Z2020 Jul2026-03-17T15:44:56.263Z2025-04-04T11:16:53.61ZS-EPMC99306163227883010.1016/j.jconrel.2020.04.007