{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zollner HJ"],"funding":["National Center for Advancing Translational Sciences","NIBIB NIH HHS","NIA NIH HHS","National Institutes of Health"],"pagination":["e4854"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9930668"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["36(3)"],"pubmed_abstract":["Expert consensus recommends linear-combination modeling (LCM) of <sup>1</sup> H MR spectra with sequence-specific simulated metabolite basis function and experimentally derived macromolecular (MM) basis functions. Measured MM basis functions are usually derived from metabolite-nulled spectra averaged across a small cohort. The use of subject-specific instead of cohort-averaged measured MM basis functions has not been studied widely. Furthermore, measured MM basis functions are not widely available to non-expert users, who commonly rely on parameterized MM signals internally simulated by LCM software. To investigate the impact of the choice of MM modeling, this study, therefore, compares metabolite level estimates between different MM modeling strategies (cohort-mean measured; subject-speci"],"journal":["NMR in biomedicine"],"pubmed_title":["Feasibility and implications of using subject-specific macromolecular spectra to model short echo time magnetic resonance spectroscopy data."],"pmcid":["PMC9930668"],"funding_grant_id":["R21 AG060245","R01 EB016089","R21A G060245","P41 EB031771","R00 AG062230","R21 EB033516","R01 EB023963"],"pubmed_authors":["Murali-Manohar S","Gong T","Hui SCN","Chen W","Edden RAE","Zollner HJ","Davies-Jenkins CW","Wang G","Oeltzschner G","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"Feasibility and implications of using subject-specific macromolecular spectra to model short echo time magnetic resonance spectroscopy data.","description":"Expert consensus recommends linear-combination modeling (LCM) of <sup>1</sup> H MR spectra with sequence-specific simulated metabolite basis function and experimentally derived macromolecular (MM) basis functions. Measured MM basis functions are usually derived from metabolite-nulled spectra averaged across a small cohort. The use of subject-specific instead of cohort-averaged measured MM basis functions has not been studied widely. Furthermore, measured MM basis functions are not widely available to non-expert users, who commonly rely on parameterized MM signals internally simulated by LCM software. To investigate the impact of the choice of MM modeling, this study, therefore, compares metabolite level estimates between different MM modeling strategies (cohort-mean measured; subject-speci","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-03T23:50:28.105Z","creation":"2025-04-03T23:50:28.105Z"},"accession":"S-EPMC9930668","cross_references":{"pubmed":["36271899"],"doi":["10.1002/nbm.4854"]}}