{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Olsen ME"],"funding":["Wisconsin Alumni Research Foundation","NIBIB NIH HHS","NICHD NIH HHS","NIMH NIH HHS","NINDS NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["710-720"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9930741"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["89(2)"],"pubmed_abstract":["<h4>Purpose</h4>In current intraoperative MRI (IMRI) methods, an iterative approach is used to aim trajectory guides at intracerebral targets: image MR-visible features, determine current aim by fitting model to image, manipulate device, repeat. Infrequent updates are produced by such methods, compared to rapid optically tracked stereotaxy used in the operating room. Our goal was to develop a real-time interactive IMRI method for aiming.<h4>Methods</h4>The current trajectory was computed from two points along the guide's central axis, rather than by imaging the entire device. These points were determined by correlating one-dimensional spokes from a radial sequence with the known cross-sectional projection of the guide. The real-time platform RTHawk was utilized to control MR sequences and data acquisition. On-screen updates were viewed by the operator while simultaneously manipulating the guide to align it with the planned trajectory. Accuracy was quantitated in a phantom, and in vivo validation was demonstrated in nonhuman primates undergoing preclinical gene (  n = 5 $$ n=5 $$  ) and cell (  n = 4 $$ n=4 $$  ) delivery surgeries.<h4>Results</h4>Updates were produced at 5 Hz In 10 phantom experiments at a depth of 48 mm, the cannula tip was placed with radial error of (min, mean, max) = (0.16, 0.29, 0.68) mm. Successful in vivo delivery of payloads to all 14 targets was demonstrated across nine surgeries with depths of (min, mean, max) = (33.3, 37.9, 42.5) mm.<h4>Conclusion</h4>A real-time interactive update rate was achieved, reducing operator fatigue without compromising accuracy. Qualitative interpretation of images during aiming was rendered unnecessary by objectively computing device alignment."],"journal":["Magnetic resonance in medicine"],"pubmed_title":["Real-time trajectory guide tracking for intraoperative MRI-guided neurosurgery."],"pmcid":["PMC9930741"],"funding_grant_id":["Accelerator program","R01 MH081884","R01 MH046729","R01‐MH081884","R01NS076352","T32 EB011434","P51OD011106","U54 HD090256","R01-MH046729","R01 NS096282","R01‐MH046729","R01 NS076352","P51 OD011106"],"pubmed_authors":["Riedel MK","Mueller SAL","Olsen ME","Kalin NH","Zhang SC","Brunner KG","Metzger JM","Oler JA","Tao Y","Brodsky EK","Vermilyea SC","Emborg ME","Ahmed AS","Block WF"],"additional_accession":[]},"is_claimable":false,"name":"Real-time trajectory guide tracking for intraoperative MRI-guided neurosurgery.","description":"<h4>Purpose</h4>In current intraoperative MRI (IMRI) methods, an iterative approach is used to aim trajectory guides at intracerebral targets: image MR-visible features, determine current aim by fitting model to image, manipulate device, repeat. Infrequent updates are produced by such methods, compared to rapid optically tracked stereotaxy used in the operating room. Our goal was to develop a real-time interactive IMRI method for aiming.<h4>Methods</h4>The current trajectory was computed from two points along the guide's central axis, rather than by imaging the entire device. These points were determined by correlating one-dimensional spokes from a radial sequence with the known cross-sectional projection of the guide. The real-time platform RTHawk was utilized to control MR sequences and data acquisition. On-screen updates were viewed by the operator while simultaneously manipulating the guide to align it with the planned trajectory. Accuracy was quantitated in a phantom, and in vivo validation was demonstrated in nonhuman primates undergoing preclinical gene (  n = 5 $$ n=5 $$  ) and cell (  n = 4 $$ n=4 $$  ) delivery surgeries.<h4>Results</h4>Updates were produced at 5 Hz In 10 phantom experiments at a depth of 48 mm, the cannula tip was placed with radial error of (min, mean, max) = (0.16, 0.29, 0.68) mm. Successful in vivo delivery of payloads to all 14 targets was demonstrated across nine surgeries with depths of (min, mean, max) = (33.3, 37.9, 42.5) mm.<h4>Conclusion</h4>A real-time interactive update rate was achieved, reducing operator fatigue without compromising accuracy. Qualitative interpretation of images during aiming was rendered unnecessary by objectively computing device alignment.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-06-21T03:21:25.679Z","creation":"2025-04-04T00:35:41.932Z"},"accession":"S-EPMC9930741","cross_references":{"pubmed":["36128887"],"doi":["10.1002/mrm.29426"]}}