{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ghatak S"],"funding":["NIDDK NIH HHS","NINR NIH HHS","NIGMS NIH HHS"],"pagination":["454-470"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9931555"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(2)"],"pubmed_abstract":["Fetal cutaneous wound closure and repair differ from that in adulthood. In this work, we identify an oxidant stress sensor protein, nonselenocysteine-containing phospholipid hydroperoxide glutathione peroxidase (NPGPx), that is abundantly expressed in normal fetal epidermis (and required for fetal wound closure), though not in adult epidermis, but is variably re-induced upon adult tissue wounding. NPGPx is a direct target of the miR-29 family. Following injury, abundance of miR-29 is lowered, permitting a prompt increase in NPGPx transcripts and protein expression in adult wound-edge tissue. NPGPx expression was required to mediate increased keratinocyte migration induced by miR-29 inhibition in vitro and in vivo. Increased NPGPx expression induced increased SOX2 expression and β-catenin n"],"journal":["Molecular therapy : the journal of the American Society of Gene Therapy"],"pubmed_title":["Driving adult tissue repair via re-engagement of a pathway required for fetal healing."],"pmcid":["PMC9931555"],"funding_grant_id":["R01 GM077185","R56 DK076566","R01 GM069589","R01 NR013898","K25 GM143572","R01 GM108014","R01 DK076566","R01 DK114718"],"pubmed_authors":["Ghatak S","Wilgus TA","Wulff BC","Sen CK","Xuan Y","Sharma A","Palakurti R","Ghosh N","Khanna S","Roy S","El Masry MS","Maulik N","Thirunavukkarasu M","Pradeep SR","Yoder MC"],"additional_accession":[]},"is_claimable":false,"name":"Driving adult tissue repair via re-engagement of a pathway required for fetal healing.","description":"Fetal cutaneous wound closure and repair differ from that in adulthood. In this work, we identify an oxidant stress sensor protein, nonselenocysteine-containing phospholipid hydroperoxide glutathione peroxidase (NPGPx), that is abundantly expressed in normal fetal epidermis (and required for fetal wound closure), though not in adult epidermis, but is variably re-induced upon adult tissue wounding. NPGPx is a direct target of the miR-29 family. Following injury, abundance of miR-29 is lowered, permitting a prompt increase in NPGPx transcripts and protein expression in adult wound-edge tissue. NPGPx expression was required to mediate increased keratinocyte migration induced by miR-29 inhibition in vitro and in vivo. Increased NPGPx expression induced increased SOX2 expression and β-catenin n","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-05-29T21:29:39.935Z","creation":"2025-05-29T21:29:39.935Z"},"accession":"S-EPMC9931555","cross_references":{"pubmed":["36114673"],"doi":["10.1016/j.ymthe.2022.09.002"]}}