{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Armstrong A"],"funding":["National Institute on Alcohol Abuse and Alcoholism","NIAAA NIH HHS"],"pagination":["531-545"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9931652"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["240(3)"],"pubmed_abstract":["<h4>Rationale</h4>Stress may contribute to relapse to alcohol use in part by enhancing reactivity to cues previously paired with alcohol. Yet, standard models of stress-induced reinstatement generally use contingent presentations of alcohol-paired cues to reinforce instrumental behaviors, making it difficult to isolate the ability of cues to invigorate alcohol-seeking.<h4>Objective</h4>Here we sought to test the impact of stress on behavioral responses to alcohol-paired cues, using a model of stress-induced reinstatement of Pavlovian conditioned approach, inspired by Nadia Chaudhri's work on context-induced reinstatement.<h4>Methods</h4>Long Evans rats were trained to associate one auditory cue with delivery of alcohol or sucrose and an alternative auditory cue with no reward. Following ex"],"journal":["Psychopharmacology"],"pubmed_title":["Reinstatement of Pavlovian responses to alcohol cues by stress."],"pmcid":["PMC9931652"],"funding_grant_id":["R00AA025384","K99 AA025384","R00 AA025384","K99AA025384"],"pubmed_authors":["Stout N","Rosenthal H","Richard JM","Armstrong A"],"additional_accession":[]},"is_claimable":false,"name":"Reinstatement of Pavlovian responses to alcohol cues by stress.","description":"<h4>Rationale</h4>Stress may contribute to relapse to alcohol use in part by enhancing reactivity to cues previously paired with alcohol. Yet, standard models of stress-induced reinstatement generally use contingent presentations of alcohol-paired cues to reinforce instrumental behaviors, making it difficult to isolate the ability of cues to invigorate alcohol-seeking.<h4>Objective</h4>Here we sought to test the impact of stress on behavioral responses to alcohol-paired cues, using a model of stress-induced reinstatement of Pavlovian conditioned approach, inspired by Nadia Chaudhri's work on context-induced reinstatement.<h4>Methods</h4>Long Evans rats were trained to associate one auditory cue with delivery of alcohol or sucrose and an alternative auditory cue with no reward. Following ex","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-03T23:50:02.695Z","creation":"2025-04-03T23:50:02.695Z"},"accession":"S-EPMC9931652","cross_references":{"pubmed":["36227353"],"doi":["10.1007/s00213-022-06255-w"]}}