biostudies-literatureArmstrong ANational Institute on Alcohol Abuse and AlcoholismNIAAA NIH HHS531-545https://www.ebi.ac.uk/biostudies/studies/S-EPMC9931652biostudies-literatureUnknown240(3)<h4>Rationale</h4>Stress may contribute to relapse to alcohol use in part by enhancing reactivity to cues previously paired with alcohol. Yet, standard models of stress-induced reinstatement generally use contingent presentations of alcohol-paired cues to reinforce instrumental behaviors, making it difficult to isolate the ability of cues to invigorate alcohol-seeking.<h4>Objective</h4>Here we sought to test the impact of stress on behavioral responses to alcohol-paired cues, using a model of stress-induced reinstatement of Pavlovian conditioned approach, inspired by Nadia Chaudhri's work on context-induced reinstatement.<h4>Methods</h4>Long Evans rats were trained to associate one auditory cue with delivery of alcohol or sucrose and an alternative auditory cue with no reward. Following exPsychopharmacologyReinstatement of Pavlovian responses to alcohol cues by stress.PMC9931652R00AA025384K99 AA025384R00 AA025384K99AA025384Stout NRosenthal HRichard JMArmstrong AfalseReinstatement of Pavlovian responses to alcohol cues by stress.<h4>Rationale</h4>Stress may contribute to relapse to alcohol use in part by enhancing reactivity to cues previously paired with alcohol. Yet, standard models of stress-induced reinstatement generally use contingent presentations of alcohol-paired cues to reinforce instrumental behaviors, making it difficult to isolate the ability of cues to invigorate alcohol-seeking.<h4>Objective</h4>Here we sought to test the impact of stress on behavioral responses to alcohol-paired cues, using a model of stress-induced reinstatement of Pavlovian conditioned approach, inspired by Nadia Chaudhri's work on context-induced reinstatement.<h4>Methods</h4>Long Evans rats were trained to associate one auditory cue with delivery of alcohol or sucrose and an alternative auditory cue with no reward. Following ex2023-01-01T00:00:00Z2023 Mar2025-04-03T23:50:02.695Z2025-04-03T23:50:02.695ZS-EPMC99316523622735310.1007/s00213-022-06255-w