biostudies-literatureUnknown43(4)Gragnani L<h4>Purpose</h4>Mixed cryoglobulinemia syndrome (MCs) is a rare immunoproliferative systemic disorder with cutaneous and multiple organ involvement. Our multicenter survey study aimed to investigate the prevalence and outcome of COVID-19 and the safety and immunogenicity of COVID-19 vaccines in a large MCs series.<h4>Methods</h4>The survey included 430 unselected MCs patients (130 M, 300 F; mean age 70 ± 10.96 years) consecutively collected at 11 Italian referral centers. Disease classification, clinico-serological assessment, COVID-19 tests, and vaccination immunogenicity were carried out according to current methodologies.<h4>Results</h4>A significantly higher prevalence of COVID-19 was found in MCs patients compared to Italian general population (11.9% vs 8.0%, p < 0.005), and the use oJournal of clinical immunology680-691https://www.ebi.ac.uk/biostudies/studies/S-EPMC9933006biostudies-literatureCOVID-19 and Mixed Cryoglobulinemia Syndrome: Long-Term Survey Study on the Prevalence and Outcome, Vaccine Safety, and Immunogenicity.PMC9933006Gragnani LRuscitti PCasato MUrraro TSantini SACacciapaglia FFerri CScarpato STreppo EIannone FMazzaro CLauletta GPetraccia LAntonelli APuccetti LDel Frate GScorpiniti DMonti MVisentini MBasili SCusano GNaclerio CElia GTavoni AMarri SFallahi PRaimondo VQuartuccio LZignego ALDi Cola ILorini SfalseCOVID-19 and Mixed Cryoglobulinemia Syndrome: Long-Term Survey Study on the Prevalence and Outcome, Vaccine Safety, and Immunogenicity.<h4>Purpose</h4>Mixed cryoglobulinemia syndrome (MCs) is a rare immunoproliferative systemic disorder with cutaneous and multiple organ involvement. Our multicenter survey study aimed to investigate the prevalence and outcome of COVID-19 and the safety and immunogenicity of COVID-19 vaccines in a large MCs series.<h4>Methods</h4>The survey included 430 unselected MCs patients (130 M, 300 F; mean age 70 ± 10.96 years) consecutively collected at 11 Italian referral centers. Disease classification, clinico-serological assessment, COVID-19 tests, and vaccination immunogenicity were carried out according to current methodologies.<h4>Results</h4>A significantly higher prevalence of COVID-19 was found in MCs patients compared to Italian general population (11.9% vs 8.0%, p < 0.005), and the use o2023-01-01T00:00:00Z2023 May2025-04-22T20:57:47.887Z2024-11-06T12:50:35.218ZS-EPMC99330063679526410.1007/s10875-023-01444-4