{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jalanka J"],"funding":["Academy of Finland","National Institute for Health Research (NIHR)","NIHR Nottingham Biomedical Research Centre","NIHR Nottingham Clinical Research Facilities"],"pagination":["451-459"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9933158"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["72(3)"],"pubmed_abstract":["<h4>Objectives</h4>Persistent bowel dysfunction following gastroenteritis (postinfectious (PI)-BD) is well recognised, but the associated changes in microbiota remain unclear. Our aim was to define these changes after gastroenteritis caused by a single organism, <i>Campylobacter jejuni</i>, examining the dynamic changes in the microbiota and the impact of antibiotics.<h4>Design</h4>A single-centre cohort study of 155 patients infected with <i>Campylobacter jejuni</i>. Features of the initial illness as well as current bowel symptoms and the intestinal microbiota composition were recorded soon after infection (visit 1, <40 days) as well as 40-60 days and >80 days later (visits 2 and 3). Microbiota were assessed using 16S rRNA sequencing.<h4>Results</h4>PI-BD was found in 22 of the 99 patien"],"journal":["Gut"],"pubmed_title":["Postinfective bowel dysfunction following <i>Campylobacter enteritis</i> is characterised by reduced microbiota diversity and impaired microbiota recovery."],"pmcid":["PMC9933158"],"funding_grant_id":["N/A","316338","15/74/01"],"pubmed_authors":["Singh G","James L","Jalanka J","Spiller RC","Finnegan L","Krishnasamy S","Nowak A","Lingaya M","Gunn D","Crispie F","Cotter P","Major G"],"additional_accession":[]},"is_claimable":false,"name":"Postinfective bowel dysfunction following <i>Campylobacter enteritis</i> is characterised by reduced microbiota diversity and impaired microbiota recovery.","description":"<h4>Objectives</h4>Persistent bowel dysfunction following gastroenteritis (postinfectious (PI)-BD) is well recognised, but the associated changes in microbiota remain unclear. Our aim was to define these changes after gastroenteritis caused by a single organism, <i>Campylobacter jejuni</i>, examining the dynamic changes in the microbiota and the impact of antibiotics.<h4>Design</h4>A single-centre cohort study of 155 patients infected with <i>Campylobacter jejuni</i>. Features of the initial illness as well as current bowel symptoms and the intestinal microbiota composition were recorded soon after infection (visit 1, <40 days) as well as 40-60 days and >80 days later (visits 2 and 3). Microbiota were assessed using 16S rRNA sequencing.<h4>Results</h4>PI-BD was found in 22 of the 99 patien","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-06-13T06:11:12.363Z","creation":"2024-10-15T05:28:54.687Z"},"accession":"S-EPMC9933158","cross_references":{"pubmed":["36171082"],"doi":["10.1136/gutjnl-2021-326828"]}}