biostudies-literatureJalanka JAcademy of FinlandNational Institute for Health Research (NIHR)NIHR Nottingham Biomedical Research CentreNIHR Nottingham Clinical Research Facilities451-459https://www.ebi.ac.uk/biostudies/studies/S-EPMC9933158biostudies-literatureUnknown72(3)<h4>Objectives</h4>Persistent bowel dysfunction following gastroenteritis (postinfectious (PI)-BD) is well recognised, but the associated changes in microbiota remain unclear. Our aim was to define these changes after gastroenteritis caused by a single organism, <i>Campylobacter jejuni</i>, examining the dynamic changes in the microbiota and the impact of antibiotics.<h4>Design</h4>A single-centre cohort study of 155 patients infected with <i>Campylobacter jejuni</i>. Features of the initial illness as well as current bowel symptoms and the intestinal microbiota composition were recorded soon after infection (visit 1, <40 days) as well as 40-60 days and >80 days later (visits 2 and 3). Microbiota were assessed using 16S rRNA sequencing.<h4>Results</h4>PI-BD was found in 22 of the 99 patienGutPostinfective bowel dysfunction following <i>Campylobacter enteritis</i> is characterised by reduced microbiota diversity and impaired microbiota recovery.PMC9933158N/A31633815/74/01Singh GJames LJalanka JSpiller RCFinnegan LKrishnasamy SNowak ALingaya MGunn DCrispie FCotter PMajor GfalsePostinfective bowel dysfunction following <i>Campylobacter enteritis</i> is characterised by reduced microbiota diversity and impaired microbiota recovery.<h4>Objectives</h4>Persistent bowel dysfunction following gastroenteritis (postinfectious (PI)-BD) is well recognised, but the associated changes in microbiota remain unclear. Our aim was to define these changes after gastroenteritis caused by a single organism, <i>Campylobacter jejuni</i>, examining the dynamic changes in the microbiota and the impact of antibiotics.<h4>Design</h4>A single-centre cohort study of 155 patients infected with <i>Campylobacter jejuni</i>. Features of the initial illness as well as current bowel symptoms and the intestinal microbiota composition were recorded soon after infection (visit 1, <40 days) as well as 40-60 days and >80 days later (visits 2 and 3). Microbiota were assessed using 16S rRNA sequencing.<h4>Results</h4>PI-BD was found in 22 of the 99 patien2023-01-01T00:00:00Z2023 Mar2026-06-13T06:11:12.363Z2024-10-15T05:28:54.687ZS-EPMC99331583617108210.1136/gutjnl-2021-326828