{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Adamowicz DH"],"funding":["NIMH NIH HHS","National Institute of Mental Health","National Institutes of Health"],"pagination":["106-113"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9933244"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["149"],"pubmed_abstract":["<h4>Background</h4>Cognitive dysfunction in schizophrenia is the key predictor of functional disability and drives economic burden. Inflammation has been increasingly implicated in the pathogenesis of schizophrenia, yet its role in cognitive decline has not been evaluated. This study explores the association between inflammation and cognitive functioning in persons with schizophrenia.<h4>Methods</h4>Participants included 143 persons with schizophrenia (PwS) and 139 non-psychiatric comparison subjects (NCs) from an ongoing study of aging. Cognitive assessments included validated measures for executive functioning, processing speed, and visuospatial skills. Plasma levels of nine biomarkers associated with inflammation (high sensitivity C-reactive protein, intercellular adhesion molecule 1, s"],"journal":["Journal of psychiatric research"],"pubmed_title":["Associations between inflammatory marker profiles and neurocognitive functioning in people with schizophrenia and non-psychiatric comparison subjects."],"pmcid":["PMC9933244"],"funding_grant_id":["K23 MH118435","R25 MH101072","K23 MH119375"],"pubmed_authors":["Shilling PD","Nguyen TT","Jeste DV","Irwin MR","Wang E","Lee EE","Liu C","Adamowicz DH","Tu X","Palmer BW"],"additional_accession":[]},"is_claimable":false,"name":"Associations between inflammatory marker profiles and neurocognitive functioning in people with schizophrenia and non-psychiatric comparison subjects.","description":"<h4>Background</h4>Cognitive dysfunction in schizophrenia is the key predictor of functional disability and drives economic burden. Inflammation has been increasingly implicated in the pathogenesis of schizophrenia, yet its role in cognitive decline has not been evaluated. This study explores the association between inflammation and cognitive functioning in persons with schizophrenia.<h4>Methods</h4>Participants included 143 persons with schizophrenia (PwS) and 139 non-psychiatric comparison subjects (NCs) from an ongoing study of aging. Cognitive assessments included validated measures for executive functioning, processing speed, and visuospatial skills. Plasma levels of nine biomarkers associated with inflammation (high sensitivity C-reactive protein, intercellular adhesion molecule 1, s","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-22T18:23:44.127Z","creation":"2025-04-06T02:29:12.617Z"},"accession":"S-EPMC9933244","cross_references":{"pubmed":["35259663"],"doi":["10.1016/j.jpsychires.2022.02.029"]}}