{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Moore SC"],"funding":["British Heart Foundation","FIC NIH HHS","Medical Research Council","The Francis Crick Institute","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["191-215.e9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9933851"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(3)"],"pubmed_abstract":["<h4>Background</h4>Both infection and vaccination, alone or in combination, generate antibody and T cell responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the maintenance of such responses-and hence protection from disease-requires careful characterization. In a large prospective study of UK healthcare workers (HCWs) (Protective Immunity from T Cells in Healthcare Workers [PITCH], within the larger SARS-CoV-2 Immunity and Reinfection Evaluation [SIREN] study), we previously observed that prior infection strongly affected subsequent cellular and humoral immunity induced after long and short dosing intervals of BNT162b2 (Pfizer/BioNTech) vaccination.<h4>Methods</h4>Here, we report longer follow-up of 684 HCWs in this cohort over 6-9 months following two"],"journal":["Med (New York, N.Y.)"],"pubmed_title":["Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens."],"pmcid":["PMC9933851"],"funding_grant_id":["WT109965MA","D43 TW009127","FS/18/52/33808","MR/W02067X/1","NIHR203792","COV19-RECPLAS","MC_UU_0025/12","PG/11/116/29288","110,110Z/15/Z","205228/Z/16/Z","NIHR300669","NIHR200907","CL-2013-07-005","COVID-19-RECPLAS","090532/Z/09/Z","MR/W020564/1","CL-2018-13-007","NF-SI-0617-10139","211153/Z/18/Z","MR/X001598/1","204721/Z/16/Z","PG/11/116/29,288","110110/Z/15/Z","MR/X009297/1","NIHR300791","CC2223","110058/Z/15/Z"],"pubmed_authors":["Dobson SL","Brown A","Tyerman JK","Newman TAH","Longet S","Carroll M","Wilson JD","Pollard AJ","Nicols AR","Meardon N","Zhang P","Deeks AS","Al-Taei S","Grouneva I","Abraham P","Supasa P","de Silva TI","Booth LH","Klenerman P","Plowright M","Dold C","Lambe T","Screaton G","Murray SM","Hall V","Tipton T","Jeffery K","Turtle L","Hering LM","Stafford L","Bibi S","Adele S","Angyal A","Shields A","Barnes E","Rowland-Jones SL","Dejnirattisai W","Neale I","Reyes LS","Tuekprakhon A","Kronsteiner B","Horner EC","Hornsby H","Nell JM","Mongkolsapaya J","Hopkins S","Conlon CP","Faustini S","Wootton DG","Duncan CJA","Richter A","Cross A","Mentzer AJ","Zewdie M","Phillips E","Thaventhiran JED","Ali M","Matthews PC","Payne RP","Malone T","Dunachie S","Liu C","PITCH Consortium","Moore SC","Brown R"],"additional_accession":[]},"is_claimable":false,"name":"Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens.","description":"<h4>Background</h4>Both infection and vaccination, alone or in combination, generate antibody and T cell responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the maintenance of such responses-and hence protection from disease-requires careful characterization. In a large prospective study of UK healthcare workers (HCWs) (Protective Immunity from T Cells in Healthcare Workers [PITCH], within the larger SARS-CoV-2 Immunity and Reinfection Evaluation [SIREN] study), we previously observed that prior infection strongly affected subsequent cellular and humoral immunity induced after long and short dosing intervals of BNT162b2 (Pfizer/BioNTech) vaccination.<h4>Methods</h4>Here, we report longer follow-up of 684 HCWs in this cohort over 6-9 months following two","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-05-28T10:47:33.344Z","creation":"2024-11-09T21:37:04.894Z"},"accession":"S-EPMC9933851","cross_references":{"pubmed":["36863347"],"doi":["10.1016/j.medj.2023.02.004"]}}