{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Stickel KC"],"funding":["NCATS NIH HHS","NEI NIH HHS","NIDA NIH HHS","NIDDK NIH HHS","NCI NIH HHS"],"pubmed_abstract":["<h4>Objective</h4>Spinophilin is an F-actin binding and protein phosphatase 1 (PP1) targeting protein that acts as a scaffold of PP1 to its substrates. Spinophilin knockout (Spino<sup>-/-</sup>) mice have decreased fat mass, increased lean mass, and improved glucose tolerance, with no difference in feeding behaviors. While spinophilin is enriched in neurons, its roles in non-neuronal tissues, such as beta cells of the pancreatic islets, are unclear.<h4>Methods & results</h4>We have corroborated and expanded upon previous studies to determine that Spino<sup>-/-</sup> mice have decreased weight gain and improved glucose tolerance in two different models of obesity. Using proteomics and immunoblotting-based approaches we identified multiple putative spinophilin interacting proteins isolated f"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.02.07.527495"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9934546"],"repository":["biostudies-literature"],"pubmed_title":["Mechanisms of spinophilin-dependent pancreas dysregulation underlying diabesity."],"pmcid":["PMC9934546"],"funding_grant_id":["R33 DA041876","R15 EY033968","P30 CA082709","R21 DA041876","UL1 TR002529","P30 DK097512"],"pubmed_authors":["Belecky-Adams TL","Baucum AJ","Doud EH","Mosley AL","Stickel KC"],"additional_accession":[]},"is_claimable":false,"name":"Mechanisms of spinophilin-dependent pancreas dysregulation underlying diabesity.","description":"<h4>Objective</h4>Spinophilin is an F-actin binding and protein phosphatase 1 (PP1) targeting protein that acts as a scaffold of PP1 to its substrates. Spinophilin knockout (Spino<sup>-/-</sup>) mice have decreased fat mass, increased lean mass, and improved glucose tolerance, with no difference in feeding behaviors. While spinophilin is enriched in neurons, its roles in non-neuronal tissues, such as beta cells of the pancreatic islets, are unclear.<h4>Methods & results</h4>We have corroborated and expanded upon previous studies to determine that Spino<sup>-/-</sup> mice have decreased weight gain and improved glucose tolerance in two different models of obesity. Using proteomics and immunoblotting-based approaches we identified multiple putative spinophilin interacting proteins isolated f","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T11:35:20.936Z","creation":"2025-04-04T11:35:20.936Z"},"accession":"S-EPMC9934546","cross_references":{"pubmed":["36798361"],"doi":["10.1101/2023.02.07.527495"]}}