{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Yin K"],"funding":["NCRR NIH HHS","NIDDK NIH HHS","NIAID NIH HHS","NIH HHS"],"pubmed_abstract":["Long COVID (LC), a type of post-acute sequelae of SARS-CoV-2 infection (PASC), occurs after at least 10% of SARS-CoV-2 infections, yet its etiology remains poorly understood. Here, we used multiple \"omics\" assays (CyTOF, RNAseq/scRNAseq, Olink) and serology to deeply characterize both global and SARS-CoV-2-specific immunity from blood of individuals with clear LC and non-LC clinical trajectories, 8 months following infection and prior to receipt of any SARS-CoV-2 vaccine. Our analysis focused on deep phenotyping of T cells, which play important roles in immunity against SARS-CoV-2 yet may also contribute to COVID-19 pathogenesis. Our findings demonstrate that individuals with LC exhibit systemic inflammation and immune dysregulation. This is evidenced by global differences in T cell subset"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.02.09.527892"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9934605"],"repository":["biostudies-literature"],"pubmed_title":["Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2."],"pmcid":["PMC9934605"],"funding_grant_id":["P30 DK063720","K23 AI146268","R01 AI141003","S10 OD018040","K23 AI157875","L30 AI126521","L30 AI147159","S10 RR028962","R01 AI158013"],"pubmed_authors":["Anglin K","Standker L","Peluso MJ","Ma T","Lopez M","Asare K","Thomas R","Munch J","Henrich TJ","Andrew A","Argueta U","Deveau TM","Huang B","Roan NR","Lee SA","Neidleman J","Martin JN","Valdivieso D","Munter SE","Shin MG","Ibrahim R","Lu S","Lynch KL","Hoh R","Kelly JD","Luo X","Young K","Goldberg SA","Yin K","Deeks SG"],"additional_accession":[]},"is_claimable":false,"name":"Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2.","description":"Long COVID (LC), a type of post-acute sequelae of SARS-CoV-2 infection (PASC), occurs after at least 10% of SARS-CoV-2 infections, yet its etiology remains poorly understood. Here, we used multiple \"omics\" assays (CyTOF, RNAseq/scRNAseq, Olink) and serology to deeply characterize both global and SARS-CoV-2-specific immunity from blood of individuals with clear LC and non-LC clinical trajectories, 8 months following infection and prior to receipt of any SARS-CoV-2 vaccine. Our analysis focused on deep phenotyping of T cells, which play important roles in immunity against SARS-CoV-2 yet may also contribute to COVID-19 pathogenesis. Our findings demonstrate that individuals with LC exhibit systemic inflammation and immune dysregulation. This is evidenced by global differences in T cell subset","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2026-04-08T13:39:19.478Z","creation":"2024-12-03T18:09:18.8Z"},"accession":"S-EPMC9934605","cross_references":{"pubmed":["36798286"],"doi":["10.1101/2023.02.09.527892"]}}