biostudies-literatureUnknownYin KNCRR NIH HHSNIDDK NIH HHSNIAID NIH HHSNIH HHSLong COVID (LC), a type of post-acute sequelae of SARS-CoV-2 infection (PASC), occurs after at least 10% of SARS-CoV-2 infections, yet its etiology remains poorly understood. Here, we used multiple "omics" assays (CyTOF, RNAseq/scRNAseq, Olink) and serology to deeply characterize both global and SARS-CoV-2-specific immunity from blood of individuals with clear LC and non-LC clinical trajectories, 8 months following infection and prior to receipt of any SARS-CoV-2 vaccine. Our analysis focused on deep phenotyping of T cells, which play important roles in immunity against SARS-CoV-2 yet may also contribute to COVID-19 pathogenesis. Our findings demonstrate that individuals with LC exhibit systemic inflammation and immune dysregulation. This is evidenced by global differences in T cell subsetbioRxiv : the preprint server for biology2023.02.09.527892https://www.ebi.ac.uk/biostudies/studies/S-EPMC9934605biostudies-literatureLong COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2.PMC9934605P30 DK063720K23 AI146268R01 AI141003S10 OD018040K23 AI157875L30 AI126521L30 AI147159S10 RR028962R01 AI158013Anglin KStandker LPeluso MJMa TLopez MAsare KThomas RMunch JHenrich TJAndrew AArgueta UDeveau TMHuang BRoan NRLee SANeidleman JMartin JNValdivieso DMunter SEShin MGIbrahim RLu SLynch KLHoh RKelly JDLuo XYoung KGoldberg SAYin KDeeks SGfalseLong COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2.Long COVID (LC), a type of post-acute sequelae of SARS-CoV-2 infection (PASC), occurs after at least 10% of SARS-CoV-2 infections, yet its etiology remains poorly understood. Here, we used multiple "omics" assays (CyTOF, RNAseq/scRNAseq, Olink) and serology to deeply characterize both global and SARS-CoV-2-specific immunity from blood of individuals with clear LC and non-LC clinical trajectories, 8 months following infection and prior to receipt of any SARS-CoV-2 vaccine. Our analysis focused on deep phenotyping of T cells, which play important roles in immunity against SARS-CoV-2 yet may also contribute to COVID-19 pathogenesis. Our findings demonstrate that individuals with LC exhibit systemic inflammation and immune dysregulation. This is evidenced by global differences in T cell subset2023-01-01T00:00:00Z2023 Aug2026-04-08T13:39:19.478Z2024-12-03T18:09:18.8ZS-EPMC99346053679828610.1101/2023.02.09.527892