{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peng M"],"funding":["Zhejiang Chinese Medical University (ZCMU)","Zhejiang Chinese Medical University","National Natural Science Foundation of China","Chinese Medicine Research Program of Zhejiang Province","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["184"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9935535"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(1)"],"pubmed_abstract":["Hypoxia and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) accumulation form the profibrogenic liver environment, which involves fibrogenesis and chronic stimulation of hepatic stellate cells (HSCs). Catalase (CAT) is the major antioxidant enzyme that catalyzes H<sub>2</sub>O<sub>2</sub> into oxygen and water, which loses its activity in different liver diseases, especially in liver fibrosis. Clinical specimens of cirrhosis patients and liver fibrotic mice are collected in this work, and results show that CAT decrease is closely correlated with hypoxia-induced transforminmg growth factor β1 (TGF-β1). A multifunctional nanosystem combining CAT-like MnO<sub>2</sub> and anti-fibrosis Saikosaponin b1 (Ssb1) is subsequently constructed for antifibrotic therapy. MnO<sub>2</sub> catalyzes the acc"],"journal":["Communications biology"],"pubmed_title":["Nanodrug rescues liver fibrosis via synergistic therapy with H<sub>2</sub>O<sub>2</sub> depletion and Saikosaponin b1 sustained release."],"pmcid":["PMC9935535"],"funding_grant_id":["81922073","2022ZQ032","52003246","2018ZY004","2021ZZ009","2021JKZKTS007A","81973481"],"pubmed_authors":["Shen Z","Dong H","Cao G","Hao M","Shao M","Han X","Yang Q","Tang D","Kuang H","Peng M","Lyu Q","Wang K"],"additional_accession":[]},"is_claimable":false,"name":"Nanodrug rescues liver fibrosis via synergistic therapy with H<sub>2</sub>O<sub>2</sub> depletion and Saikosaponin b1 sustained release.","description":"Hypoxia and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) accumulation form the profibrogenic liver environment, which involves fibrogenesis and chronic stimulation of hepatic stellate cells (HSCs). Catalase (CAT) is the major antioxidant enzyme that catalyzes H<sub>2</sub>O<sub>2</sub> into oxygen and water, which loses its activity in different liver diseases, especially in liver fibrosis. Clinical specimens of cirrhosis patients and liver fibrotic mice are collected in this work, and results show that CAT decrease is closely correlated with hypoxia-induced transforminmg growth factor β1 (TGF-β1). A multifunctional nanosystem combining CAT-like MnO<sub>2</sub> and anti-fibrosis Saikosaponin b1 (Ssb1) is subsequently constructed for antifibrotic therapy. MnO<sub>2</sub> catalyzes the acc","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-05-18T13:25:16.25Z","creation":"2025-05-18T13:25:16.25Z"},"accession":"S-EPMC9935535","cross_references":{"pubmed":["36797395"],"doi":["10.1038/s42003-023-04473-2"]}}