biostudies-literatureKeijzer HMNIBIB NIH HHSRijnstate-radboud promotion fundFoundation for the National Institutes of HealthNIMH NIH HHSZonMwHartstichting2139-2148https://www.ebi.ac.uk/biostudies/studies/S-EPMC9935650biostudies-literatureUnknown33(3)<h4>Objectives</h4>Approximately 50% of comatose patients after cardiac arrest never regain consciousness. Cerebral ischaemia may lead to cytotoxic and/or vasogenic oedema, which can be detected by diffusion tensor imaging (DTI). Here, we evaluate the potential value of free water corrected mean diffusivity (MD) and fractional anisotropy (FA) based on DTI, for the prediction of neurological recovery of comatose patients after cardiac arrest.<h4>Methods</h4>A total of 50 patients after cardiac arrest were included in this prospective cohort study in two Dutch hospitals. DTI was obtained 2-4 days after cardiac arrest. Outcome was assessed at 6 months, dichotomised as poor (cerebral performance category 3-5; n = 20) or good (n = 30) neurological outcome. We calculated the whole brain mean MD European radiologyFree water corrected diffusion tensor imaging discriminates between good and poor outcomes of comatose patients after cardiac arrest.PMC99356502012T077P41 EB0159022018T070R01 MH074794NIH R01MH074794NIH P41EB015902015008048Duering MPasternak OMeijer FJABlans MJHofmeijer JKlijn CJMVerhulst MMLHHoedemaekers CWEKeijzer HMTonino BARfalseFree water corrected diffusion tensor imaging discriminates between good and poor outcomes of comatose patients after cardiac arrest.<h4>Objectives</h4>Approximately 50% of comatose patients after cardiac arrest never regain consciousness. Cerebral ischaemia may lead to cytotoxic and/or vasogenic oedema, which can be detected by diffusion tensor imaging (DTI). Here, we evaluate the potential value of free water corrected mean diffusivity (MD) and fractional anisotropy (FA) based on DTI, for the prediction of neurological recovery of comatose patients after cardiac arrest.<h4>Methods</h4>A total of 50 patients after cardiac arrest were included in this prospective cohort study in two Dutch hospitals. DTI was obtained 2-4 days after cardiac arrest. Outcome was assessed at 6 months, dichotomised as poor (cerebral performance category 3-5; n = 20) or good (n = 30) neurological outcome. We calculated the whole brain mean MD 2023-01-01T00:00:00Z2023 Mar2026-05-28T16:54:00.206Z2025-02-19T02:56:53.131ZS-EPMC99356503641862310.1007/s00330-022-09245-w