biostudies-literatureUnknown16Takahashi E<h4>Introduction</h4>Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction, communication and repetitive, restrictive behaviors, features supported by cortical activity. Given the importance of the subventricular zone (SVZ) of the lateral ventrical to cortical development, we compared molecular, cellular, and structural differences in the SVZ and linked cortical regions in specimens of ASD cases and sex and age-matched unaffected brain.<h4>Methods</h4>We used magnetic resonance imaging (MRI) and diffusion tractography on <i>ex vivo</i> postmortem brain samples, which we further analyzed by Whole Genome Bisulfite Sequencing (WGBS), Flow Cytometry, and RT qPCR.<h4>Results</h4>Through MRI, we observed decreased tractography pathways frFrontiers in neuroscience1023665https://www.ebi.ac.uk/biostudies/studies/S-EPMC9935943biostudies-literatureIntegration of structural MRI and epigenetic analyses hint at linked cellular defects of the subventricular zone and insular cortex in autism: Findings from a case study.PMC9935943Lee RValli BTakahashi EMaunakea AKMcCracken TAOrtug AVargas-Maya NIEthier EBaumer Nvan der Kouwe AJWTsujimura KAllan NPeres RLevman JfalseIntegration of structural MRI and epigenetic analyses hint at linked cellular defects of the subventricular zone and insular cortex in autism: Findings from a case study.<h4>Introduction</h4>Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction, communication and repetitive, restrictive behaviors, features supported by cortical activity. Given the importance of the subventricular zone (SVZ) of the lateral ventrical to cortical development, we compared molecular, cellular, and structural differences in the SVZ and linked cortical regions in specimens of ASD cases and sex and age-matched unaffected brain.<h4>Methods</h4>We used magnetic resonance imaging (MRI) and diffusion tractography on <i>ex vivo</i> postmortem brain samples, which we further analyzed by Whole Genome Bisulfite Sequencing (WGBS), Flow Cytometry, and RT qPCR.<h4>Results</h4>Through MRI, we observed decreased tractography pathways fr2022-01-01T00:00:00Z20222025-04-26T14:59:58.192Z2025-04-06T14:45:13.941ZS-EPMC99359433681709910.3389/fnins.2022.1023665