biostudies-literatureDomalpally ANIA NIH HHSNIDDK NIH HHSNCRR NIH HHS140-147https://www.ebi.ac.uk/biostudies/studies/S-EPMC9936345biostudies-literatureUnknown141(2)<h4>Importance</h4>Age-related macular degeneration (AMD) is a leading cause of blindness with no treatment available for early stages. Retrospective studies have shown an association between metformin and reduced risk of AMD.<h4>Objective</h4>To investigate the association between metformin use and age-related macular degeneration (AMD).<h4>Design, setting, and participants</h4>The Diabetes Prevention Program Outcomes Study is a cross-sectional follow-up phase of a large multicenter randomized clinical trial, Diabetes Prevention Program (1996-2001), to investigate the association of treatment with metformin or an intensive lifestyle modification vs placebo with preventing the onset of type 2 diabetes in a population at high risk for developing diabetes. Participants with retinal imaging aJAMA ophthalmologyAssociation of Metformin With the Development of Age-Related Macular Degeneration.PMC9936345U01 DK048407K24 AG045334U01 DK048404U01 DK048349U01 DK048406U01 DK048443U01 DK048400U01 DK048489U01 DK048468M01 RR016587U01 DK048485U01 DK048387P30 DK020595U01 DK048380U01 DK048381P30 DK017047U01 DK048437U01 DK048514U01 DK048339U01 DK048377U01 DK048411U01 DK048434U01 DK048412U01 DK048413U01 DK048375U01 DK048397Caro JFTestaverde LHorse EKellum TSmith CFBoggs GJohnson MKBrancati FLPercy CAEnote ASmith CMKavena KLeon LSewenemewa JRoston SNgo KRochon JHeard DRyder LBudoff MHorak KBray GAMagee MFrazier MTemprosa MAdelman DTDavid KTorio-Hurley JFineberg ESVenditti EWalker TBowers AMau MKFisher ELiberoni RLevy EAldrich FABamdad JWeinzierl VMontgomery BKMiller MMcLymont VGroessl EReimers JLagarda MMarrero DGMagpuri PIsonaga MKSemler LSantiago ADiabetes Prevention Program Research (DPPOS) GroupJenkins TNyenwe EALovejoy JCSaab PHaffner SMUwaifo GAndre VLNatewa CMcNabb WChai LMucik PBaldo MNelson JAFondino AWiggins RLee CGZimmerman ETemple KAHampton EFAtler LFGiannella ALyman MLambeth HApplegate WBBurge MRFarago MBarrett-Connor ELee JEMoran RRPolonsky KSFowler SPiromalli CRuiz RSeely EWKramer MKDavis MMikami KBallonoff LBRubin RRMohideen PBarkalow MSteinke SCGoldstein AHyde PHaffner LSherman ARMayer-Davis EPompi DKatzir NGregg ESosa ALawton KEBezabeh TConzues CMcDaniel KChen LWells-Thayer DCallaghan JJanesch SSShuldiner ARPena MBSpencer CTonemah DSanguily JMartinez HFreel JPrineas RJLoman KMills MSaad MFMartinez ANashboo YLachin JMSherif HHernandez-McGinnis DABenchoff CMyers DOldmixon CFLipkin EWDonahue RPReusing JMa YJohnson SBronsord MDarwin CHSullivan ECzech KGuillory FGNavy CFultz MAbbas CPrince MJJohnson DLukin JSchroeder EBPrineas RGuido MHarden MKoenning GRicks HLove Burkott HMiddendorf JPoirier CSOlefsky JMReinhart RStevens CReidy MMendez JLeandre FAnderson EGrassa EOdom SKCanady JLWatson PGCassanova-Romero PHarris LAnderson HGoldman VLarsen DD'Anna KCarter CEFlorez JCSantiago JVPoulos ASoliman EZMugford MDuffy HCastillo-Florez SKahn SELarkin MHurt ETsai ECSangster SRowe PMosley HSalazar MChatellier AFargnoli BDanis RRubtchinsky SBucca BCNair AKKnopp RHKeasler LHivert MFKobus KMShields TCooeyate NYazzie MCook MClaravall LNRipley VGlass JArakaki RFPenn SCGohdes DGlass MTurgeon HDabelea DMCook SBegay SSeagle HJones TLBeltran MThomas AImseis RPal CJinagouda SGaniats TTadros SDohm KCalles JCantrell CMLeos DThomas LShaw RHarting JRubinchik SLongchamp NRoy RJStewart KJJeffirs MLTrandafirescu GKloiber SCalonge BNDotson YFHogan Tjaden AVicknair PCRoach PJCurtis JPutenney PMalloy MABryant MHill JOEhrmann DAMudaliar SFlorez HJCox LBarr SMendoza JBeddow RBissett LBaumhauer HWatson SYamamoto REWatson KZonszein JMcAtee GSilverman AGreene AMathioudakis NVenditti EMHubbard LGreenway FJackson MASarkin AJMorgan-Taggart ISmart MGrover-Fairchild NWalker EAAllison DBAckermann RTAdams KSBroussard BAGuare JCDotson BEdgerton CGao YBird ECPollin TIMullen MYoussef GDwyer GMDragg ARooney ESDas SAlexander TSchade DSMcCabe CBrown ALGarfield SHoskin MAStrylewicz GBillings LKMunshi MMelancon LEFoo STFujimoto WLawrence DGrant WSchwartz ABarrett NNilan TMelish JSSt Amant JAPhillips EOStamm EPerry RUEberhardt BSmith FEdelstein SLPerry ASmith JPan JJay PPoirier SAdorno ESmith MBassiouni SWildman WPerreault LKula LMBenson MBPan QWhite NHKhare-Ranade PWing RRPatel AChew EYSoberman JEWilliams KVOtto ATaylor TCheatham WWChristophi CGoldstein BJTaylor LChampagne CMGoldberg RBMetzger BEJortberg BTRoumain JWilliams-Cleaves BBethepu JAronoff NJBotrous MDuncan RSemenske ARPalermo LBryer-Ash MGanda OPKatz PAbbott KKatz REwen APepe CLorenzo CGurry LGilligan RHall SDelve LHorton ESDailing CBrown JODolgoff JVeciana BHenry RRHu JCallaphan KMShapiro SKnowler WCNicosia MJohannes CWilliams RAltshuler DSenter WWylie-Rosett JGuimond SKitabchi AEGoulding AJablonski KBradley VHoward-Century CJParkes KCola SPettigrew JDowden JMDodge CSanford DARegensteiner JGJackson SDLevatan CKirby LPolonsky WBrown MBLatimer RWGhahate JMSchweizer DDuncan CHorne JMatulik MJOrchard TManus CBoraz MGama VCulbert IWGuidi AMolitch MECarrion-Petersen MLOrlosky RTulley RTLockett Mde Groot MLou PCorkery EKirkman MSColleran KClifford LOktaei HHarrier SSchinleber PADacawyma TBehrends CLara OLarreal CSapozhnikova ARyan DHRubinstein DInouye JAbebe SKelly SMScheindlin JCulyba RFriedler ACohn HSaudek CDBrenneman TPinner KLRassam AHoyer SREvans GHurtenbach CGottlieb AEvans CLamkin MLarsen MDJohnson CKHPak JTrence DLi YViscovich KAColegrove CAlbers JNathan DMFitzgibbon MVanDorsten BFradkin JElsas DCrandall JJones SWarram JJones TLedbury SAnderson DRJacobsen AMGooding RDelahanty LSwift MCaballero EMarr MRowland NDFranklin TMurphy MEKolinjivadi PPorter BDRaymond EBermudez NEBain RTobian JJackson MHoffman HLindsay MMurillo AWheeler MLDomalpally ADeSandre CSimonson DSwift KWalker-Murray FZhang ZCappelli SKrakoff JMontez MGHattaway KRockette-Wagner BTruong JWilson TSamuels AZachwieja JJEdelman SVKocal MClark BFurlong KHamman RFClark DNoel AFattaleh BZhang PWallia AVejvoda KRatner RESmith LLHemphill CGiles MMWhittier SAButler NJeffries SChong HHerbert AAKaskalla RSAgharanya NKerr MJiggetts DSimmons MSolomon CGArceneaux JBurke JPKurland JCagliero EManjoo QPemberton NHanson RLDagogo-Jack SCharleston JBFranks PWShamoon HIbebuogu UEngel SLichtermann LCKessler DEndres RWhittington TLee CPowell DMarcovina SPitts TPrice DWKriska AAndon NRowse DHagamen SEastman RPolczynski EWernimont CArky RAMcPherson DHazuda HPAllen AO'Leary DSmith KGMichaels SWilson CReamer SGrimes KLActon KJLenz DSmith KAGibbs PRautaharju PHilbrich RLambert LSpandorfer JBenz WHadden AUtsey ERainville RGolden SHBarber RSansoucy JBrown ERautaharju FNash PVPassaro MBondi KHensley SBudget MGarg RBouffard ALowe ARutledge LMKVan Wye GEHClark JMPark JIgnaut JMLuchsinger JAXapthalamous KHerman WHBoyle PJMorris LHStimpson CChavez MManly JPi-Sunyer FXStephens SDoughty MSBrandle MO'Neal KTseng BIsaac JVargo PSpellman JGonzales YMiddelbeek RJWWilliamson DQuitingon MWilliamson PCrandall JPBaker-Ladao NKBlodi BFrieson SLBavido-Arrage CIngraham LEAkbar KMcKitrick CKriska AMStich TKing CViolino EKennedy BMGadde KMBucca BGarimella PAraneta MRFoulkes MMorgan TAroda VWaters DBennett PHCampbell CJoseph HDias LMather KJfalseAssociation of Metformin With the Development of Age-Related Macular Degeneration.<h4>Importance</h4>Age-related macular degeneration (AMD) is a leading cause of blindness with no treatment available for early stages. Retrospective studies have shown an association between metformin and reduced risk of AMD.<h4>Objective</h4>To investigate the association between metformin use and age-related macular degeneration (AMD).<h4>Design, setting, and participants</h4>The Diabetes Prevention Program Outcomes Study is a cross-sectional follow-up phase of a large multicenter randomized clinical trial, Diabetes Prevention Program (1996-2001), to investigate the association of treatment with metformin or an intensive lifestyle modification vs placebo with preventing the onset of type 2 diabetes in a population at high risk for developing diabetes. Participants with retinal imaging a2023-01-01T00:00:00Z2023 Feb2026-05-28T18:01:35.568Z2025-04-06T16:30:25.254ZS-EPMC99363453654796710.1001/jamaophthalmol.2022.5567