biostudies-literatureUnknown18Ye LBacterial has become a common pathogen of humans owing to their drug-resistant effects and evasion of the host immune system, with their ability to form biofilm and induce severe infections, a condition which has become a primary public health concern globally. Herein, we report on CuO@AgO/ZnO NPs antibacterial activity enhanced by near-infrared (NIR) light which was effective in the elimination of <i>Staphylococcus aureus</i> and the <i>Pseudomonas aeruginosa</i>. The CuO@AgO/ZnO NPs under NIR significantly eradicated <i>S. aureus</i> and its biofilm and <i>P. aeruginosa in vitro</i>, and subsequently exhibited such phenomenon <i>in vivo</i>, eliminating bacteria and healing wound. This demonstrated the combined intrinsic antibacterial potency of the Cu and Ag components of the CuO@AgO/ZnMaterials today. Bio100552https://www.ebi.ac.uk/biostudies/studies/S-EPMC9936377biostudies-literatureThe CuO and AgO co-modified ZnO nanocomposites for promoting wound healing in <i>Staphylococcus aureus</i> infection.PMC9936377Ye LShen JHe XWang DShen TObeng EHu RDeng HZheng DfalseThe CuO and AgO co-modified ZnO nanocomposites for promoting wound healing in <i>Staphylococcus aureus</i> infection.Bacterial has become a common pathogen of humans owing to their drug-resistant effects and evasion of the host immune system, with their ability to form biofilm and induce severe infections, a condition which has become a primary public health concern globally. Herein, we report on CuO@AgO/ZnO NPs antibacterial activity enhanced by near-infrared (NIR) light which was effective in the elimination of <i>Staphylococcus aureus</i> and the <i>Pseudomonas aeruginosa</i>. The CuO@AgO/ZnO NPs under NIR significantly eradicated <i>S. aureus</i> and its biofilm and <i>P. aeruginosa in vitro</i>, and subsequently exhibited such phenomenon <i>in vivo</i>, eliminating bacteria and healing wound. This demonstrated the combined intrinsic antibacterial potency of the Cu and Ag components of the CuO@AgO/Zn2023-01-01T00:00:00Z2023 Feb2025-04-26T14:56:13.839Z2025-04-06T14:44:12.52ZS-EPMC99363773681975610.1016/j.mtbio.2023.100552