{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["141(4)"],"submitter":["Bothun ED"],"pubmed_abstract":["<h4>Importance</h4>Glaucoma can develop following cataract removal in children.<h4>Objective</h4>To assess the cumulative incidence of glaucoma-related adverse events (defined as glaucoma or glaucoma suspect) and factors associated with risk of these adverse events in the first 5 years after lensectomy prior to 13 years of age.<h4>Design, setting, and participants</h4>This cohort study used longitudinal registry data collected at enrollment and annually for 5 years from 45 institutional and 16 community sites. Participants were children aged 12 years or younger with at least 1 office visit after lensectomy from June 2012 to July 2015. Data were analyzed from February through December 2022.<h4>Exposures</h4>Usual clinical care after lensectomy.<h4>Main outcomes and measures</h4>The main outcomes were cumulative incidence of glaucoma-related adverse events and baseline factors associated with risk of these adverse events.<h4>Results</h4>The study included 810 children (1049 eyes); 443 eyes of 321 children (55% female; mean [SD] age, 0.89 [1.97] years) were aphakic after lensectomy, and 606 eyes of 489 children (53% male; mean [SD] age, 5.65 [3.32] years) were pseudophakic. The 5-year cumulative incidence of glaucoma-related adverse events was 29% (95% CI, 25%-34%) in 443 eyes with aphakia and 7% (95% CI, 5%-9%) in 606 eyes with pseudophakia; 7% (95% CI, 5%-10%) of aphakic eyes and 3% (95% CI, 2%-5%) of pseudophakic eyes were diagnosed as glaucoma suspect. Among aphakic eyes, a higher risk for glaucoma-related adverse events was associated with 4 of 8 factors, including age less than 3 months (vs ≥3 months: adjusted hazard ratio [aHR], 2.88; 99% CI, 1.57-5.23), abnormal anterior segment (vs normal: aHR, 2.88; 99% CI, 1.56-5.30), intraoperative complications at time of lensectomy (vs none; aHR, 2.25; 99% CI, 1.04-4.87), and bilaterality (vs unilaterality: aHR, 1.88; 99% CI, 1.02-3.48). Neither of the 2 factors evaluated for pseudophakic eyes, laterality and anterior vitrectomy, were associated with risk of glaucoma-related adverse events.<h4>Conclusions and relevance</h4>In this cohort study, glaucoma-related adverse events were common after cataract surgery in children; age less than 3 months at surgery was associated with elevated risk of the adverse events in aphakic eyes. Children with pseudophakia, who were older at surgery, less frequently developed a glaucoma-related adverse event within 5 years of lensectomy. The findings suggest that ongoing monitoring for the development of glaucoma is needed after lensectomy at any age."],"journal":["JAMA ophthalmology"],"pagination":["324-331"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9936384"],"repository":["biostudies-literature"],"pubmed_title":["Incidence of Glaucoma-Related Adverse Events in the First 5 Years After Pediatric Lensectomy."],"pmcid":["PMC9936384"],"pubmed_authors":["Conner CL","Suh D","Herlihy EP","Sanders EN","Yanovitch TL","Kieser T","Lingua R","Taylor K","Colburn J","Grijalva J","Kraus CL","Astle WF","Fisher A","Haider KM","Ralay-Ranaivo H","Christiansen SP","Poff SW","Trumler AA","Hoepner JE","Bothun ED","Neiman AE","Prakalapakorn S","Phelps DL","Shea C","Hashmi T","Burkman D","Whitehead GF","Yoon H","Hug D","Rosado J","Hatt SR","Golden R","Salvin JH","Belanger C","Manny RE","Dean TW","Clausius DA","Henderson RJ","Klein S","Whitfill CR","Hemberger JC","Strominger MB","Welnick N","Enyedi LB","Colon B","Van Iderstine SC","Austin DS","Repka MX","de Alba Campomanes AG","Cotter SA","Hammond BP","Baker JD","Cruz OA","Schloff S","Ventura G","Peters RJ","Shan X","Birch EE","Chen V","Davis B","Kemmer JD","Traboulsi E","Hilbrands J","Kraker RT","Sauberan DP","Li Z","Wilson LB","Leske DA","Lenhart P","Robinson JL","Rahmani B","Fimbel BP","Davis PL","Hamidullah A","Peterson CH","Jordan C","McConnell KH","Holmes JM","Liu X","Melia BM","Baran F","Areaux R","Sala NA","Yen KG","Silver JL","Khammar AJ","Tamkins SM","Larson SA","Robertson E","Yang MB","Pediatric Eye Disease Investigator Group","Stahl ED","Mets-Halgrimson R","Pineles SL","Melese E","Gandhi N","Guo S","Mendoza MN","Park HS","Frohwein JJ","Dent RJ","O'Hara M","Tychsen L","LaRoche GR","Jin J","Longmuir S","Quebbemann M","Oravec SA","Rudaitis I","Droste PJ","Beck RW","Superstein R","Benson SL","Peterson E","Hercinovic A","Chamberlain C","Stutz KM","Everett DF","Stillman SM","Sala AM","Ortiz G","Bradfield YS","Orge F","Foster NC","Mellott M","McOwen DC","Clarke MP","Holleschau AM","Powell C","McCourt EA","Brower J","Wheeler AM","Brickman-Kelleher J","Ramsey JE","Ruark ST","Azar NF","Jones SK","Kong L","Diener-West M","Lee KA","Thibeault M","Verderber LC","Anninger W","Smith JM","Chang T","Gearinger MD","Salchow DJ","Schweinler BR","Hendricks DH","Lunsford K","Wernimont SM","Baker J","Donahue Q","Lowery RS","Ticho BH","Anderson JS","Wallace DK","Kurup SP","Woodard VC","Brooks D","Singh J","Erzurum SA","Wang S","Summers AI","Weise KK","Wu R","Whitaker ME","Bernardo MJ","Therriault M","Gray ME","Gladstone A","Madigan WP","Sutherland DR","Karp KA","Lambert SR","Bremer D","Ghasia F","Friedman I","Galvin J","Freedman SF","Dittman E","Karr DJ","Young MP","Gallerson BK","Cassady C","Mohney BG","Baird AM","Kaplon JD","Rogers D","Hutchinson AK","Boyle NM","Morrison DG","Saunders RA","Grigorian AP","Smith H","Plager DA","Smith J","Fallaha N","Ghadban R","Bowman CS","Rauch PK","Neilsen RA","Czubinski A","Kumar K","Shah B","Cupit S","Govreau D","Hamel P","Nye C","Crouch ER","Chandler DL"],"additional_accession":[]},"is_claimable":false,"name":"Incidence of Glaucoma-Related Adverse Events in the First 5 Years After Pediatric Lensectomy.","description":"<h4>Importance</h4>Glaucoma can develop following cataract removal in children.<h4>Objective</h4>To assess the cumulative incidence of glaucoma-related adverse events (defined as glaucoma or glaucoma suspect) and factors associated with risk of these adverse events in the first 5 years after lensectomy prior to 13 years of age.<h4>Design, setting, and participants</h4>This cohort study used longitudinal registry data collected at enrollment and annually for 5 years from 45 institutional and 16 community sites. Participants were children aged 12 years or younger with at least 1 office visit after lensectomy from June 2012 to July 2015. Data were analyzed from February through December 2022.<h4>Exposures</h4>Usual clinical care after lensectomy.<h4>Main outcomes and measures</h4>The main outcomes were cumulative incidence of glaucoma-related adverse events and baseline factors associated with risk of these adverse events.<h4>Results</h4>The study included 810 children (1049 eyes); 443 eyes of 321 children (55% female; mean [SD] age, 0.89 [1.97] years) were aphakic after lensectomy, and 606 eyes of 489 children (53% male; mean [SD] age, 5.65 [3.32] years) were pseudophakic. The 5-year cumulative incidence of glaucoma-related adverse events was 29% (95% CI, 25%-34%) in 443 eyes with aphakia and 7% (95% CI, 5%-9%) in 606 eyes with pseudophakia; 7% (95% CI, 5%-10%) of aphakic eyes and 3% (95% CI, 2%-5%) of pseudophakic eyes were diagnosed as glaucoma suspect. Among aphakic eyes, a higher risk for glaucoma-related adverse events was associated with 4 of 8 factors, including age less than 3 months (vs ≥3 months: adjusted hazard ratio [aHR], 2.88; 99% CI, 1.57-5.23), abnormal anterior segment (vs normal: aHR, 2.88; 99% CI, 1.56-5.30), intraoperative complications at time of lensectomy (vs none; aHR, 2.25; 99% CI, 1.04-4.87), and bilaterality (vs unilaterality: aHR, 1.88; 99% CI, 1.02-3.48). Neither of the 2 factors evaluated for pseudophakic eyes, laterality and anterior vitrectomy, were associated with risk of glaucoma-related adverse events.<h4>Conclusions and relevance</h4>In this cohort study, glaucoma-related adverse events were common after cataract surgery in children; age less than 3 months at surgery was associated with elevated risk of the adverse events in aphakic eyes. Children with pseudophakia, who were older at surgery, less frequently developed a glaucoma-related adverse event within 5 years of lensectomy. The findings suggest that ongoing monitoring for the development of glaucoma is needed after lensectomy at any age.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-06-14T05:36:04.893Z","creation":"2025-04-06T03:56:15.779Z"},"accession":"S-EPMC9936384","cross_references":{"pubmed":["36795393"],"doi":["10.1001/jamaophthalmol.2022.6413"]}}