biostudies-literatureUnknown141(4)Bothun ED<h4>Importance</h4>Glaucoma can develop following cataract removal in children.<h4>Objective</h4>To assess the cumulative incidence of glaucoma-related adverse events (defined as glaucoma or glaucoma suspect) and factors associated with risk of these adverse events in the first 5 years after lensectomy prior to 13 years of age.<h4>Design, setting, and participants</h4>This cohort study used longitudinal registry data collected at enrollment and annually for 5 years from 45 institutional and 16 community sites. Participants were children aged 12 years or younger with at least 1 office visit after lensectomy from June 2012 to July 2015. Data were analyzed from February through December 2022.<h4>Exposures</h4>Usual clinical care after lensectomy.<h4>Main outcomes and measures</h4>The main outcomes were cumulative incidence of glaucoma-related adverse events and baseline factors associated with risk of these adverse events.<h4>Results</h4>The study included 810 children (1049 eyes); 443 eyes of 321 children (55% female; mean [SD] age, 0.89 [1.97] years) were aphakic after lensectomy, and 606 eyes of 489 children (53% male; mean [SD] age, 5.65 [3.32] years) were pseudophakic. The 5-year cumulative incidence of glaucoma-related adverse events was 29% (95% CI, 25%-34%) in 443 eyes with aphakia and 7% (95% CI, 5%-9%) in 606 eyes with pseudophakia; 7% (95% CI, 5%-10%) of aphakic eyes and 3% (95% CI, 2%-5%) of pseudophakic eyes were diagnosed as glaucoma suspect. Among aphakic eyes, a higher risk for glaucoma-related adverse events was associated with 4 of 8 factors, including age less than 3 months (vs ≥3 months: adjusted hazard ratio [aHR], 2.88; 99% CI, 1.57-5.23), abnormal anterior segment (vs normal: aHR, 2.88; 99% CI, 1.56-5.30), intraoperative complications at time of lensectomy (vs none; aHR, 2.25; 99% CI, 1.04-4.87), and bilaterality (vs unilaterality: aHR, 1.88; 99% CI, 1.02-3.48). Neither of the 2 factors evaluated for pseudophakic eyes, laterality and anterior vitrectomy, were associated with risk of glaucoma-related adverse events.<h4>Conclusions and relevance</h4>In this cohort study, glaucoma-related adverse events were common after cataract surgery in children; age less than 3 months at surgery was associated with elevated risk of the adverse events in aphakic eyes. Children with pseudophakia, who were older at surgery, less frequently developed a glaucoma-related adverse event within 5 years of lensectomy. The findings suggest that ongoing monitoring for the development of glaucoma is needed after lensectomy at any age.JAMA ophthalmology324-331https://www.ebi.ac.uk/biostudies/studies/S-EPMC9936384biostudies-literatureIncidence of Glaucoma-Related Adverse Events in the First 5 Years After Pediatric Lensectomy.PMC9936384Conner CLSuh DHerlihy EPSanders ENYanovitch TLKieser TLingua RTaylor KColburn JGrijalva JKraus CLAstle WFFisher AHaider KMRalay-Ranaivo HChristiansen SPPoff SWTrumler AAHoepner JEBothun EDNeiman AEPrakalapakorn SPhelps DLShea CHashmi TBurkman DWhitehead GFYoon HHug DRosado JHatt SRGolden RSalvin JHBelanger CManny REDean TWClausius DAHenderson RJKlein SWhitfill CRHemberger JCStrominger MBWelnick NEnyedi LBColon BVan Iderstine SCAustin DSRepka MXde Alba Campomanes AGCotter SAHammond BPBaker JDCruz OASchloff SVentura GPeters RJShan XBirch EEChen VDavis BKemmer JDTraboulsi EHilbrands JKraker RTSauberan DPLi ZWilson LBLeske DALenhart PRobinson JLRahmani BFimbel BPDavis PLHamidullah APeterson CHJordan CMcConnell KHHolmes JMLiu XMelia BMBaran FAreaux RSala NAYen KGSilver JLKhammar AJTamkins SMLarson SARobertson EYang MBPediatric Eye Disease Investigator GroupStahl EDMets-Halgrimson RPineles SLMelese EGandhi NGuo SMendoza MNPark HSFrohwein JJDent RJO'Hara MTychsen LLaRoche GRJin JLongmuir SQuebbemann MOravec SARudaitis IDroste PJBeck RWSuperstein RBenson SLPeterson EHercinovic AChamberlain CStutz KMEverett DFStillman SMSala AMOrtiz GBradfield YSOrge FFoster NCMellott MMcOwen DCClarke MPHolleschau AMPowell CMcCourt EABrower JWheeler AMBrickman-Kelleher JRamsey JERuark STAzar NFJones SKKong LDiener-West MLee KAThibeault MVerderber LCAnninger WSmith JMChang TGearinger MDSalchow DJSchweinler BRHendricks DHLunsford KWernimont SMBaker JDonahue QLowery RSTicho BHAnderson JSWallace DKKurup SPWoodard VCBrooks DSingh JErzurum SAWang SSummers AIWeise KKWu RWhitaker MEBernardo MJTherriault MGray MEGladstone AMadigan WPSutherland DRKarp KALambert SRBremer DGhasia FFriedman IGalvin JFreedman SFDittman EKarr DJYoung MPGallerson BKCassady CMohney BGBaird AMKaplon JDRogers DHutchinson AKBoyle NMMorrison DGSaunders RAGrigorian APSmith HPlager DASmith JFallaha NGhadban RBowman CSRauch PKNeilsen RACzubinski AKumar KShah BCupit SGovreau DHamel PNye CCrouch ERChandler DLfalseIncidence of Glaucoma-Related Adverse Events in the First 5 Years After Pediatric Lensectomy.<h4>Importance</h4>Glaucoma can develop following cataract removal in children.<h4>Objective</h4>To assess the cumulative incidence of glaucoma-related adverse events (defined as glaucoma or glaucoma suspect) and factors associated with risk of these adverse events in the first 5 years after lensectomy prior to 13 years of age.<h4>Design, setting, and participants</h4>This cohort study used longitudinal registry data collected at enrollment and annually for 5 years from 45 institutional and 16 community sites. Participants were children aged 12 years or younger with at least 1 office visit after lensectomy from June 2012 to July 2015. Data were analyzed from February through December 2022.<h4>Exposures</h4>Usual clinical care after lensectomy.<h4>Main outcomes and measures</h4>The main outcomes were cumulative incidence of glaucoma-related adverse events and baseline factors associated with risk of these adverse events.<h4>Results</h4>The study included 810 children (1049 eyes); 443 eyes of 321 children (55% female; mean [SD] age, 0.89 [1.97] years) were aphakic after lensectomy, and 606 eyes of 489 children (53% male; mean [SD] age, 5.65 [3.32] years) were pseudophakic. The 5-year cumulative incidence of glaucoma-related adverse events was 29% (95% CI, 25%-34%) in 443 eyes with aphakia and 7% (95% CI, 5%-9%) in 606 eyes with pseudophakia; 7% (95% CI, 5%-10%) of aphakic eyes and 3% (95% CI, 2%-5%) of pseudophakic eyes were diagnosed as glaucoma suspect. Among aphakic eyes, a higher risk for glaucoma-related adverse events was associated with 4 of 8 factors, including age less than 3 months (vs ≥3 months: adjusted hazard ratio [aHR], 2.88; 99% CI, 1.57-5.23), abnormal anterior segment (vs normal: aHR, 2.88; 99% CI, 1.56-5.30), intraoperative complications at time of lensectomy (vs none; aHR, 2.25; 99% CI, 1.04-4.87), and bilaterality (vs unilaterality: aHR, 1.88; 99% CI, 1.02-3.48). Neither of the 2 factors evaluated for pseudophakic eyes, laterality and anterior vitrectomy, were associated with risk of glaucoma-related adverse events.<h4>Conclusions and relevance</h4>In this cohort study, glaucoma-related adverse events were common after cataract surgery in children; age less than 3 months at surgery was associated with elevated risk of the adverse events in aphakic eyes. Children with pseudophakia, who were older at surgery, less frequently developed a glaucoma-related adverse event within 5 years of lensectomy. The findings suggest that ongoing monitoring for the development of glaucoma is needed after lensectomy at any age.2023-01-01T00:00:00Z2023 Apr2026-06-14T05:36:04.893Z2025-04-06T03:56:15.779ZS-EPMC99363843679539310.1001/jamaophthalmol.2022.6413