{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Duffy KA"],"funding":["NIMH NIH HHS"],"pagination":["7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9936707"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["<h4>Background</h4>The mechanisms by which parental early life stress can be transmitted to the next generation, in some cases in a sex-specific manner, are unclear. Maternal preconception stress may increase susceptibility to suboptimal health outcomes via in utero programming of the fetal hypothalamic-pituitary-adrenal (HPA) axis.<h4>Methods</h4>We recruited healthy pregnant women (N = 147), dichotomized into low (0 or 1) and high (2+) adverse childhood experience (ACE) groups based on the ACE Questionnaire, to test the hypothesis that maternal ACE history influences fetal adrenal development in a sex-specific manner. At a mean (standard deviation) of 21.5 (1.4) and 29.5 (1.4) weeks gestation, participants underwent three-dimensional ultrasounds to measure fetal adrenal volume, adjusting"],"journal":["Biology of sex differences"],"pubmed_title":["Maternal adverse childhood experiences impact fetal adrenal volume in a sex-specific manner."],"pmcid":["PMC9936707"],"funding_grant_id":["P50 MH099910","K23MH102360"],"pubmed_authors":["Wang EY","Bale TL","Duffy KA","Epperson CN","Sammel MD","Johnson RL","Hantsoo L","Kim DR","Ewing G","Kornfield SL"],"additional_accession":[]},"is_claimable":false,"name":"Maternal adverse childhood experiences impact fetal adrenal volume in a sex-specific manner.","description":"<h4>Background</h4>The mechanisms by which parental early life stress can be transmitted to the next generation, in some cases in a sex-specific manner, are unclear. Maternal preconception stress may increase susceptibility to suboptimal health outcomes via in utero programming of the fetal hypothalamic-pituitary-adrenal (HPA) axis.<h4>Methods</h4>We recruited healthy pregnant women (N = 147), dichotomized into low (0 or 1) and high (2+) adverse childhood experience (ACE) groups based on the ACE Questionnaire, to test the hypothesis that maternal ACE history influences fetal adrenal development in a sex-specific manner. At a mean (standard deviation) of 21.5 (1.4) and 29.5 (1.4) weeks gestation, participants underwent three-dimensional ultrasounds to measure fetal adrenal volume, adjusting","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T13:35:48.099Z","creation":"2025-02-19T02:56:57.866Z"},"accession":"S-EPMC9936707","cross_references":{"pubmed":["36803442"],"doi":["10.1186/s13293-023-00492-0"]}}