{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yamamoto T"],"funding":["Japan Society for the Promotion of Science"],"pagination":["e0281746"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9937502"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(2)"],"pubmed_abstract":["The apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)/caspase-1/interleukin(IL)-1β axis, also known as the inflammasome pathway, is indispensable for IL-1β activation in response to various pathogens or own damages. Previously, we developed an NLRP3-inflammasome using a cell-free system and identified ASC targeting drugs; thus, examination of ASC-related histopathology in various diseases could help to provide indications for these drugs. Here, we generated mice deficient only in ASC-protein (ASC-deficient (AD) mice) using CRISPR/Cas9 technology, studied which tissues were most affected, and obtained histopathological images of lipopolysaccharide (LPS)-induced endotoxemia. C57BL/6 wild-type (WT) and (AD) mice were injected intraperitoneally with a lethal"],"journal":["PloS one"],"pubmed_title":["Intestinal edema induced by LPS-induced endotoxemia is associated with an inflammasome adaptor ASC."],"pmcid":["PMC9937502"],"funding_grant_id":["20H03719, 22K19438","20K07376"],"pubmed_authors":["Kaneko N","Kurata M","Masumoto J","Yamamoto T"],"additional_accession":[]},"is_claimable":false,"name":"Intestinal edema induced by LPS-induced endotoxemia is associated with an inflammasome adaptor ASC.","description":"The apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)/caspase-1/interleukin(IL)-1β axis, also known as the inflammasome pathway, is indispensable for IL-1β activation in response to various pathogens or own damages. Previously, we developed an NLRP3-inflammasome using a cell-free system and identified ASC targeting drugs; thus, examination of ASC-related histopathology in various diseases could help to provide indications for these drugs. Here, we generated mice deficient only in ASC-protein (ASC-deficient (AD) mice) using CRISPR/Cas9 technology, studied which tissues were most affected, and obtained histopathological images of lipopolysaccharide (LPS)-induced endotoxemia. C57BL/6 wild-type (WT) and (AD) mice were injected intraperitoneally with a lethal","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T23:12:24.355Z","creation":"2025-04-04T23:12:24.355Z"},"accession":"S-EPMC9937502","cross_references":{"pubmed":["36800329"],"doi":["10.1371/journal.pone.0281746"]}}