{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ehrlich A"],"funding":["Abbott","Sam and Rina Frankel","European Research Council","Nikoh Foundation","NIA NIH HHS","NHLBI NIH HHS"],"pagination":["e79946"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9937660"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Background
Viral infection is associated with a significant rewire of the host metabolic pathways, presenting attractive metabolic targets for intervention.Methods
We chart the metabolic response of lung epithelial cells to SARS-CoV-2 infection in primary cultures and COVID-19 patient samples and perform in vitro metabolism-focused drug screen on primary lung epithelial cells infected with different strains of the virus. We perform observational analysis of Israeli patients hospitalized due to COVID-19 and comparative epidemiological analysis from cohorts in Italy and the Veteran's Health Administration in the United States. In addition, we perform a prospective non-randomized interventional open-label study in which 15 patients hospitalized with severe COVID-19 were given "],"journal":["eLife"],"pubmed_title":["Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study."],"pmcid":["PMC9937660"],"funding_grant_id":["R01 HL157108","681870","R01 AG074989","FENOC0003"],"pubmed_authors":["Ioannidis K","Atari N","Daskal Y","Kliker L","Ehrlich A","Cohen M","Maayan SL","Pavanello C","Gottlieb A","Hofree M","Shafran Tikva S","Cohen JB","Shibolet O","Mandelboim M","Nasar M","Rainy N","Abu Alkian I","Nahmias Y","Deutsch L","Cicero A","Sirtori CR","Chirinos JA","Bar-Chaim A","Houri I"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study.","description":"Background
Viral infection is associated with a significant rewire of the host metabolic pathways, presenting attractive metabolic targets for intervention.Methods
We chart the metabolic response of lung epithelial cells to SARS-CoV-2 infection in primary cultures and COVID-19 patient samples and perform in vitro metabolism-focused drug screen on primary lung epithelial cells infected with different strains of the virus. We perform observational analysis of Israeli patients hospitalized due to COVID-19 and comparative epidemiological analysis from cohorts in Italy and the Veteran's Health Administration in the United States. In addition, we perform a prospective non-randomized interventional open-label study in which 15 patients hospitalized with severe COVID-19 were given ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-05-28T18:34:35.575Z","creation":"2024-10-18T18:20:40.899Z"},"accession":"S-EPMC9937660","cross_references":{"pubmed":["36705566"],"doi":["10.7554/eLife.79946"]}}