{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Cai X"],"pubmed_abstract":["Unhindered transportation of substances in the brain extracellular space (ECS) is essential for maintaining brain function. Regulation of transportation is a novel strategy for treating ECS blockage-related brain diseases, but few techniques have been developed to date. In this study, we established a novel approach for accelerating the drainage of brain interstitial fluid (ISF) in the ECS using minimally invasive surgery, in which a branch of the external carotid artery is separated and implanted epidurally (i.e., epidural arterial implantation [EAI]) to promote a pulsation effect on cerebrospinal fluid (CSF) in the frontoparietal region. Tracer-based magnetic resonance imaging was used to evaluate the changes in ISF drainage in rats 7 and 15 days post-EAI. The drainage of the traced ISF "],"journal":["Aging and disease"],"pagination":["219-228"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9937704"],"repository":["biostudies-literature"],"pubmed_title":["Epidural Pulsation Accelerates the Drainage of Brain Interstitial Fluid."],"pmcid":["PMC9937704"],"pubmed_authors":["Li H","Peng Y","Yan J","Li C","Kong D","Wei X","Wang H","He Q","Yin F","Li T","Jia Y","Gao Y","Han H","Wang W","Tong H","Yang S","Cai X","Ren Q"],"additional_accession":[]},"is_claimable":false,"name":"Epidural Pulsation Accelerates the Drainage of Brain Interstitial Fluid.","description":"Unhindered transportation of substances in the brain extracellular space (ECS) is essential for maintaining brain function. Regulation of transportation is a novel strategy for treating ECS blockage-related brain diseases, but few techniques have been developed to date. In this study, we established a novel approach for accelerating the drainage of brain interstitial fluid (ISF) in the ECS using minimally invasive surgery, in which a branch of the external carotid artery is separated and implanted epidurally (i.e., epidural arterial implantation [EAI]) to promote a pulsation effect on cerebrospinal fluid (CSF) in the frontoparietal region. Tracer-based magnetic resonance imaging was used to evaluate the changes in ISF drainage in rats 7 and 15 days post-EAI. The drainage of the traced ISF ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-26T14:58:29.765Z","creation":"2025-04-06T14:44:47.683Z"},"accession":"S-EPMC9937704","cross_references":{"pubmed":["36818558"],"doi":["10.14336/AD.2022.0609"]}}