{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nagao R"],"funding":["MEXT | Japan Society for the Promotion of Science","Japan Agency for Medical Research and Development"],"pagination":["920"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9938196"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Iron-stress-induced-A proteins (IsiAs) are expressed in cyanobacteria under iron-deficient conditions. The cyanobacterium Anabaena sp. PCC 7120 has four isiA genes; however, their binding property and functional roles in PSI are still missing. We analyzed a cryo-electron microscopy structure of a PSI-IsiA supercomplex isolated from Anabaena grown under an iron-deficient condition. The PSI-IsiA structure contains six IsiA subunits associated with the PsaA side of a PSI core monomer. Three of the six IsiA subunits were identified as IsiA1 and IsiA2. The PSI-IsiA structure lacks a PsaL subunit; instead, a C-terminal domain of IsiA2 occupies the position of PsaL, which inhibits the oligomerization of PSI, leading to the formation of a PSI monomer. Furthermore, excitation-energy transfer from I"],"journal":["Nature communications"],"pubmed_title":["Structure of a monomeric photosystem I core associated with iron-stress-induced-A proteins from Anabaena sp. PCC 7120."],"pmcid":["PMC9938196"],"funding_grant_id":["JP22H04916","JP20K06528","JP20H02914","JP17H06434","JP21K19085"],"pubmed_authors":["Tsuboshita N","Suzuki T","Ueno Y","Kawakami K","Shimizu S","Ehira S","Dohmae N","Furutani M","Nakajima Y","Akimoto S","Nagao R","Kato K","Shen JR","Hamaguchi T","Yonekura K"],"additional_accession":[]},"is_claimable":false,"name":"Structure of a monomeric photosystem I core associated with iron-stress-induced-A proteins from Anabaena sp. PCC 7120.","description":"Iron-stress-induced-A proteins (IsiAs) are expressed in cyanobacteria under iron-deficient conditions. The cyanobacterium Anabaena sp. PCC 7120 has four isiA genes; however, their binding property and functional roles in PSI are still missing. We analyzed a cryo-electron microscopy structure of a PSI-IsiA supercomplex isolated from Anabaena grown under an iron-deficient condition. The PSI-IsiA structure contains six IsiA subunits associated with the PsaA side of a PSI core monomer. Three of the six IsiA subunits were identified as IsiA1 and IsiA2. The PSI-IsiA structure lacks a PsaL subunit; instead, a C-terminal domain of IsiA2 occupies the position of PsaL, which inhibits the oligomerization of PSI, leading to the formation of a PSI monomer. Furthermore, excitation-energy transfer from I","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-28T16:36:48.586Z","creation":"2024-10-15T05:17:50.209Z"},"accession":"S-EPMC9938196","cross_references":{"pubmed":["36805598"],"doi":["10.1038/s41467-023-36504-1"]}}