{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mao J"],"funding":["Natural Science Foundation of Chongqing"],"pagination":["9150324"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9938769"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2023"],"pubmed_abstract":["<h4>Objective</h4>To explore the potential molecular mechanism of <i>Pueraria Lobata Radix</i> (RP) and <i>Salviae Miltiorrhizae Radix</i> (RS) in the treatment of type 2 diabetes mellitus (T2DM) based on network pharmacology and molecular docking.<h4>Methods</h4>The chemical constituents and core targets of RP and RS were searched by Traditional Chinese Medicine System Pharmacology (TCMSP); target genes related to T2DM were obtained through GeneCards database, component target network diagram was constructed, intersection genes of active compounds and T2DM were synthesized, protein-protein interaction (PPI) relationship was obtained, and core targets were screened by using Cytoscape 3.7.2. Gene Ontology (GO) biological process and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway wer"],"journal":["Computational and mathematical methods in medicine"],"pubmed_title":["Combined Network Pharmacology and Molecular Docking to Verify the Treatment of Type 2 Diabetes with <i>Pueraria Lobata Radix</i> and <i>Salviae Miltiorrhizae Radix</i>."],"pmcid":["PMC9938769"],"funding_grant_id":["cstc2021jcyjmsxmX0452","cmba2022kyym-zkxmQ0003","KJQN202002801","2020YYCXCQSJ050","ygz2022101"],"pubmed_authors":["Tan L","Li Y","Tang L","Yang L","Zhu Z","Mu Z","Tian C","Wang G","Fang L","Mao J"],"additional_accession":[]},"is_claimable":false,"name":"Combined Network Pharmacology and Molecular Docking to Verify the Treatment of Type 2 Diabetes with <i>Pueraria Lobata Radix</i> and <i>Salviae Miltiorrhizae Radix</i>.","description":"<h4>Objective</h4>To explore the potential molecular mechanism of <i>Pueraria Lobata Radix</i> (RP) and <i>Salviae Miltiorrhizae Radix</i> (RS) in the treatment of type 2 diabetes mellitus (T2DM) based on network pharmacology and molecular docking.<h4>Methods</h4>The chemical constituents and core targets of RP and RS were searched by Traditional Chinese Medicine System Pharmacology (TCMSP); target genes related to T2DM were obtained through GeneCards database, component target network diagram was constructed, intersection genes of active compounds and T2DM were synthesized, protein-protein interaction (PPI) relationship was obtained, and core targets were screened by using Cytoscape 3.7.2. Gene Ontology (GO) biological process and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway wer","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-22T10:10:03.832Z","creation":"2025-04-05T23:31:09.451Z"},"accession":"S-EPMC9938769","cross_references":{"pubmed":["36820318"],"doi":["10.1155/2023/9150324"]}}