biostudies-literatureMao JNatural Science Foundation of Chongqing9150324https://www.ebi.ac.uk/biostudies/studies/S-EPMC9938769biostudies-literatureUnknown2023<h4>Objective</h4>To explore the potential molecular mechanism of <i>Pueraria Lobata Radix</i> (RP) and <i>Salviae Miltiorrhizae Radix</i> (RS) in the treatment of type 2 diabetes mellitus (T2DM) based on network pharmacology and molecular docking.<h4>Methods</h4>The chemical constituents and core targets of RP and RS were searched by Traditional Chinese Medicine System Pharmacology (TCMSP); target genes related to T2DM were obtained through GeneCards database, component target network diagram was constructed, intersection genes of active compounds and T2DM were synthesized, protein-protein interaction (PPI) relationship was obtained, and core targets were screened by using Cytoscape 3.7.2. Gene Ontology (GO) biological process and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway werComputational and mathematical methods in medicineCombined Network Pharmacology and Molecular Docking to Verify the Treatment of Type 2 Diabetes with <i>Pueraria Lobata Radix</i> and <i>Salviae Miltiorrhizae Radix</i>.PMC9938769cstc2021jcyjmsxmX0452cmba2022kyym-zkxmQ0003KJQN2020028012020YYCXCQSJ050ygz2022101Tan LLi YTang LYang LZhu ZMu ZTian CWang GFang LMao JfalseCombined Network Pharmacology and Molecular Docking to Verify the Treatment of Type 2 Diabetes with <i>Pueraria Lobata Radix</i> and <i>Salviae Miltiorrhizae Radix</i>.<h4>Objective</h4>To explore the potential molecular mechanism of <i>Pueraria Lobata Radix</i> (RP) and <i>Salviae Miltiorrhizae Radix</i> (RS) in the treatment of type 2 diabetes mellitus (T2DM) based on network pharmacology and molecular docking.<h4>Methods</h4>The chemical constituents and core targets of RP and RS were searched by Traditional Chinese Medicine System Pharmacology (TCMSP); target genes related to T2DM were obtained through GeneCards database, component target network diagram was constructed, intersection genes of active compounds and T2DM were synthesized, protein-protein interaction (PPI) relationship was obtained, and core targets were screened by using Cytoscape 3.7.2. Gene Ontology (GO) biological process and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway wer2023-01-01T00:00:00Z20232025-04-22T10:10:03.832Z2025-04-05T23:31:09.451ZS-EPMC99387693682031810.1155/2023/9150324