{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(2)"],"submitter":["Wang N"],"pubmed_abstract":["The significance of 5-methylcytosine (m<sup>5</sup>C) methylation in human malignancies has become an increasing focus of investigation. Here, we show that m<sup>5</sup>C regulators including writers, readers and erasers, are predominantly upregulated in urothelial carcinoma of the bladder (UCB) derived from Sun Yat-sen University Cancer Center and The Cancer Genome Atlas cohort. In addition, NOP2/Sun RNA methyltransferase family member 2 (NSUN2) as a methyltransferase and Aly/REF export factor (ALYREF) as a nuclear m<sup>5</sup>C reader, are frequently coexpressed in UCB. By applying patient-derived organoids model and orthotopic xenograft mice model, we demonstrate that ALYREF enhances proliferation and invasion of UCB cells in an m<sup>5</sup>C-dependent manner. Integration of tanscript"],"journal":["Cell death & disease"],"pagination":["139"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9938871"],"repository":["biostudies-literature"],"pubmed_title":["m<sup>5</sup>C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6/TK1 mRNAs splicing and stabilization."],"pmcid":["PMC9938871"],"pubmed_authors":["Zhou ZH","Chen RX","Liu ZW","Wen JH","Ning K","Zhou FJ","Li YH","Li XD","Wang N","Ye YL","Wei WS","Zhang XP","Deng MH","Dong B"],"additional_accession":[]},"is_claimable":false,"name":"m<sup>5</sup>C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6/TK1 mRNAs splicing and stabilization.","description":"The significance of 5-methylcytosine (m<sup>5</sup>C) methylation in human malignancies has become an increasing focus of investigation. Here, we show that m<sup>5</sup>C regulators including writers, readers and erasers, are predominantly upregulated in urothelial carcinoma of the bladder (UCB) derived from Sun Yat-sen University Cancer Center and The Cancer Genome Atlas cohort. In addition, NOP2/Sun RNA methyltransferase family member 2 (NSUN2) as a methyltransferase and Aly/REF export factor (ALYREF) as a nuclear m<sup>5</sup>C reader, are frequently coexpressed in UCB. By applying patient-derived organoids model and orthotopic xenograft mice model, we demonstrate that ALYREF enhances proliferation and invasion of UCB cells in an m<sup>5</sup>C-dependent manner. Integration of tanscript","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T20:10:04.838Z","creation":"2025-02-18T22:50:53.027Z"},"accession":"S-EPMC9938871","cross_references":{"pubmed":["36806253"],"doi":["10.1038/s41419-023-05661-y"]}}