biostudies-literatureSusman SJNCATS NIH HHS1098-1107https://www.ebi.ac.uk/biostudies/studies/S-EPMC9939016biostudies-literatureUnknown7(5)<h4>Background</h4>There are many detectable changes in circulating biomarkers in the setting of myocardial ischemia. We hypothesize that there are associated changes in circulating B-type natriuretic peptide (BNP) level after stress-induced myocardial ischemia, which can be used for emergency department (ED) acute coronary syndrome (ACS) risk stratification.<h4>Methods</h4>In a prospective study, we enrolled 340 patients over the age of 30 receiving an exercise echocardiography stress test in an ED observational unit for suspected ACS. We collected blood samples at baseline and at 2 and 4 h post-stress test, measuring the relative and absolute changes (stress-delta) in plasma BNP concentrations. In addition, patients were contacted at 90 days and at 1 year posttest for a follow-up. We calThe journal of applied laboratory medicineStress-Delta B-Type Natriuretic Peptide Does Not Exclude ACS in the ED.PMC9939016UL1 TR002553Griffin SMSusman SJBouffler ALeahy JCChristenson RHNewby LKKuchibhatla MLimkakeng ATGordee AfalseStress-Delta B-Type Natriuretic Peptide Does Not Exclude ACS in the ED.<h4>Background</h4>There are many detectable changes in circulating biomarkers in the setting of myocardial ischemia. We hypothesize that there are associated changes in circulating B-type natriuretic peptide (BNP) level after stress-induced myocardial ischemia, which can be used for emergency department (ED) acute coronary syndrome (ACS) risk stratification.<h4>Methods</h4>In a prospective study, we enrolled 340 patients over the age of 30 receiving an exercise echocardiography stress test in an ED observational unit for suspected ACS. We collected blood samples at baseline and at 2 and 4 h post-stress test, measuring the relative and absolute changes (stress-delta) in plasma BNP concentrations. In addition, patients were contacted at 90 days and at 1 year posttest for a follow-up. We cal2022-01-01T00:00:00Z2022 Sep2025-04-04T22:56:04.97Z2025-04-04T22:56:04.97ZS-EPMC99390163558771110.1093/jalm/jfac027