{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Clyman RI"],"funding":["U.S. Public Health Service National Heart, Lung and Blood Institute","NHLBI NIH HHS"],"pagination":["216-223"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9940607"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["37(2)"],"pubmed_abstract":["<h4>Objective</h4>This study was aimed to examine the relationship between duration of infant exposure to a moderate-to-large patent ductus arteriosus (PDA) shunt and the risk of developing bronchopulmonary dysplasia (BPD) or death before 36 weeks (BPD/death).<h4>Study design</h4>Infants <28 weeks' gestation who survived ≥7 days (<i>n</i> = 423) had echocardiograms performed on day 7 and at planned intervals.<h4>Results</h4>In multivariable regression models, BPD/death did not appear to be increased until infants had been exposed to a moderate-to-large PDA for at least 7-13 days: OR (95%CI) (referent = closed or small PDA): moderate-to-large PDA exposure for <7 days: 0.38 (range, 0.10-1.46); for 7 to 13 days = 2.12 (range, 1.04-4.32); for ≥14 days = 3.86 (range, 2.15-6.96). Once the threshold of 7 to 13 days had been reached, additional exposure (≥14 days) did not significantly add to the increased incidence of BPD/death: (referent exposure = 7-13 days) exposure for 14 to 27 days = 1.34 (range, 0.52-3.45); for 28 to 48 days = 2.34 (range, 0.88-6.19); for ≥49 days = 1.80 (range. 0.59-5.47). A similar relationship was found for the outcome of BPD-alone.<h4>Conclusion</h4>Infants < 28 weeks' gestation required at least 7 to 13 days of exposure to a moderate-to-large PDA before a significant increase in the incidence of BPD/death was apparent. Once this threshold was reached additional exposure to a moderate-to-large PDA did not significantly add to the increased incidence of BPD/death."],"journal":["American journal of perinatology"],"pubmed_title":["Relationship between Duration of Infant Exposure to a Moderate-to-Large Patent Ductus Arteriosus Shunt and the Risk of Developing Bronchopulmonary Dysplasia or Death Before 36 Weeks."],"pmcid":["PMC9940607"],"funding_grant_id":["HL109199","R01 HL109199"],"pubmed_authors":["Liebowitz M","Johng S","Clyman RI","Hills NK"],"additional_accession":[]},"is_claimable":false,"name":"Relationship between Duration of Infant Exposure to a Moderate-to-Large Patent Ductus Arteriosus Shunt and the Risk of Developing Bronchopulmonary Dysplasia or Death Before 36 Weeks.","description":"<h4>Objective</h4>This study was aimed to examine the relationship between duration of infant exposure to a moderate-to-large patent ductus arteriosus (PDA) shunt and the risk of developing bronchopulmonary dysplasia (BPD) or death before 36 weeks (BPD/death).<h4>Study design</h4>Infants <28 weeks' gestation who survived ≥7 days (<i>n</i> = 423) had echocardiograms performed on day 7 and at planned intervals.<h4>Results</h4>In multivariable regression models, BPD/death did not appear to be increased until infants had been exposed to a moderate-to-large PDA for at least 7-13 days: OR (95%CI) (referent = closed or small PDA): moderate-to-large PDA exposure for <7 days: 0.38 (range, 0.10-1.46); for 7 to 13 days = 2.12 (range, 1.04-4.32); for ≥14 days = 3.86 (range, 2.15-6.96). Once the threshold of 7 to 13 days had been reached, additional exposure (≥14 days) did not significantly add to the increased incidence of BPD/death: (referent exposure = 7-13 days) exposure for 14 to 27 days = 1.34 (range, 0.52-3.45); for 28 to 48 days = 2.34 (range, 0.88-6.19); for ≥49 days = 1.80 (range. 0.59-5.47). A similar relationship was found for the outcome of BPD-alone.<h4>Conclusion</h4>Infants < 28 weeks' gestation required at least 7 to 13 days of exposure to a moderate-to-large PDA before a significant increase in the incidence of BPD/death was apparent. Once this threshold was reached additional exposure to a moderate-to-large PDA did not significantly add to the increased incidence of BPD/death.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2024-12-03T21:46:13.34Z","creation":"2024-12-03T21:46:13.34Z"},"accession":"S-EPMC9940607","cross_references":{"pubmed":["31600791"],"doi":["10.1055/s-0039-1697672"]}}