{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(1)"],"submitter":["Treyer A"],"pubmed_abstract":["<h4>Introduction</h4>Treatment with cannabis extracts for a variety of diseases has gained popularity. However, differences in herb-drug interaction potential of extracts from different plant sources are poorly understood. In this study, we provide a characterization of cannabis extracts prepared from four cannabis chemotypes and an in vitro assessment of their Cytochrome P450 (CYP)-mediated herb-drug interaction profiles.<h4>Methods</h4>Plant extracts were either commercially obtained or prepared using ethanol as solvent, followed by overnight decarboxylation in a reflux condenser system. The extracts were characterized for their cannabinoid content using NMR and HPLC-PDA-ELSD-ESIMS. CYP inhibition studies with the cannabis extracts and pure cannabinoids (tetrahydrocannabinol [THC] and ca"],"journal":["Medical cannabis and cannabinoids"],"pagination":["21-31"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9940649"],"repository":["biostudies-literature"],"pubmed_title":["Phytochemical Comparison of Medicinal Cannabis Extracts and Study of Their CYP-Mediated Interactions with Coumarinic Oral Anticoagulants."],"pmcid":["PMC9940649"],"pubmed_authors":["Oufir M","Treyer A","Eigenmann DE","Reinhardt JK","Hamburger M"],"additional_accession":[]},"is_claimable":false,"name":"Phytochemical Comparison of Medicinal Cannabis Extracts and Study of Their CYP-Mediated Interactions with Coumarinic Oral Anticoagulants.","description":"<h4>Introduction</h4>Treatment with cannabis extracts for a variety of diseases has gained popularity. However, differences in herb-drug interaction potential of extracts from different plant sources are poorly understood. In this study, we provide a characterization of cannabis extracts prepared from four cannabis chemotypes and an in vitro assessment of their Cytochrome P450 (CYP)-mediated herb-drug interaction profiles.<h4>Methods</h4>Plant extracts were either commercially obtained or prepared using ethanol as solvent, followed by overnight decarboxylation in a reflux condenser system. The extracts were characterized for their cannabinoid content using NMR and HPLC-PDA-ELSD-ESIMS. CYP inhibition studies with the cannabis extracts and pure cannabinoids (tetrahydrocannabinol [THC] and ca","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan-Dec","modification":"2026-03-17T16:06:28.42Z","creation":"2025-04-06T14:44:37.179Z"},"accession":"S-EPMC9940649","cross_references":{"pubmed":["36814687"],"doi":["10.1159/000528465"]}}