{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Freijy TM"],"pubmed_abstract":["<h4>Background</h4>Preliminary evidence supports the use of dietary interventions and gut microbiota-targeted interventions such as probiotic or prebiotic supplementation for improving mental health. We report on the first randomised controlled trial (RCT) to examine the effects of a high-prebiotic dietary intervention and probiotic supplements on mental health.<h4>Methods</h4>\"Gut Feelings\" was an 8-week, 2 × 2 factorial RCT of 119 adults with moderate psychological distress and low prebiotic food intake. Treatment arms: (1) probiotic supplement and diet-as-usual (probiotic group); (2) high-prebiotic diet and placebo supplement (prebiotic diet group); (3) probiotic supplement and high-prebiotic diet (synbiotic group); and (4) placebo supplement and diet-as-usual (placebo group). The prima"],"journal":["Frontiers in neuroscience"],"pagination":["1097278"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9940791"],"repository":["biostudies-literature"],"pubmed_title":["Effects of a high-prebiotic diet versus probiotic supplements versus synbiotics on adult mental health: The \"Gut Feelings\" randomised controlled trial."],"pmcid":["PMC9940791"],"pubmed_authors":["Freijy TM","Metri NJ","Opie RS","Jacka FN","Hawrelak JA","Ng CH","Oliver G","Cribb L","Sarris J","Rucklidge JJ"],"additional_accession":[]},"is_claimable":false,"name":"Effects of a high-prebiotic diet versus probiotic supplements versus synbiotics on adult mental health: The \"Gut Feelings\" randomised controlled trial.","description":"<h4>Background</h4>Preliminary evidence supports the use of dietary interventions and gut microbiota-targeted interventions such as probiotic or prebiotic supplementation for improving mental health. We report on the first randomised controlled trial (RCT) to examine the effects of a high-prebiotic dietary intervention and probiotic supplements on mental health.<h4>Methods</h4>\"Gut Feelings\" was an 8-week, 2 × 2 factorial RCT of 119 adults with moderate psychological distress and low prebiotic food intake. Treatment arms: (1) probiotic supplement and diet-as-usual (probiotic group); (2) high-prebiotic diet and placebo supplement (prebiotic diet group); (3) probiotic supplement and high-prebiotic diet (synbiotic group); and (4) placebo supplement and diet-as-usual (placebo group). The prima","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T14:59:44.117Z","creation":"2025-04-06T14:45:11.089Z"},"accession":"S-EPMC9940791","cross_references":{"pubmed":["36815026"],"doi":["10.3389/fnins.2022.1097278"]}}