{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee YJ"],"funding":["Seoul Metropolitan Government Seoul National University Boramae Medical Center"],"pagination":["e63"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9941013"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(7)"],"pubmed_abstract":["<h4>Background</h4>This study investigated the relationship between fibroblast growth factor 21 (FGF21) levels and growth in children with growth hormone deficiency (GHD) and idiopathic short stature (ISS), and the effects of the FGF21 level on response to growth hormone (GH) treatment.<h4>Methods</h4>We included 171 pre-pubertal children with a GHD (n = 54), ISS (n = 46), and normal height (n = 71). Fasting FGF21 levels were measured at baseline and every 6 months during GH treatment. Factors associated with growth velocity (GV) after GH therapy were investigated.<h4>Results</h4>The FGF21 level was higher in short children than in the controls without significant difference between the GHD and ISS groups. In the GHD group, the FGF21 level was inversely associated with the free fatty acid "],"journal":["Journal of Korean medical science"],"pubmed_title":["Relationship Between the Serum FGF21 Level and Growth in Children of Short Stature."],"pmcid":["PMC9941013"],"funding_grant_id":["03-2018-17"],"pubmed_authors":["Lee YA","Jung SY","Lee SY","Lee YJ","Kim J","Shin CH"],"additional_accession":[]},"is_claimable":false,"name":"Relationship Between the Serum FGF21 Level and Growth in Children of Short Stature.","description":"<h4>Background</h4>This study investigated the relationship between fibroblast growth factor 21 (FGF21) levels and growth in children with growth hormone deficiency (GHD) and idiopathic short stature (ISS), and the effects of the FGF21 level on response to growth hormone (GH) treatment.<h4>Methods</h4>We included 171 pre-pubertal children with a GHD (n = 54), ISS (n = 46), and normal height (n = 71). Fasting FGF21 levels were measured at baseline and every 6 months during GH treatment. Factors associated with growth velocity (GV) after GH therapy were investigated.<h4>Results</h4>The FGF21 level was higher in short children than in the controls without significant difference between the GHD and ISS groups. In the GHD group, the FGF21 level was inversely associated with the free fatty acid ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-22T11:14:37.264Z","creation":"2025-04-05T23:50:27.198Z"},"accession":"S-EPMC9941013","cross_references":{"pubmed":["36808549"],"doi":["10.3346/jkms.2023.38.e63"]}}