biostudies-literatureCheng LNCI NIH HHSNIAMS NIH HHSE129-E137https://www.ebi.ac.uk/biostudies/studies/S-EPMC9941076biostudies-literatureUnknown46(2)<h4>Background</h4>Some children and adolescents receiving chemotherapy experience few symptom-related adverse events, whereas others experience multiple adverse events. If oncology nurses could identify patients likely to have pronounced chemotherapy-related adverse events, tailored supportive care could be matched to these patients' symptom burdens.<h4>Objective</h4>The aim of this study was to identify symptom profiles in children and adolescents before and after chemotherapy, and the sociodemographic and psychological factors associated with profile classification and change.<h4>Methods</h4>Participants ranging from 7 to 18 years (n = 436) completed 6 Patient-Reported Outcomes Measurement Information System pediatric symptom measures within 72 hours preceding (T1) and 1 to 2 weeks afteCancer nursingProfiles of Symptom Suffering and Functioning in Children and Adolescents Receiving Chemotherapy.PMC9941076R01 CA175759U19 AR069522Mann CMReeve BBWithycombe JSWaldron MKCheng LJacobs SSHinds PSMack JWMaurer SHWeaver MWang JBaker JNfalseProfiles of Symptom Suffering and Functioning in Children and Adolescents Receiving Chemotherapy.<h4>Background</h4>Some children and adolescents receiving chemotherapy experience few symptom-related adverse events, whereas others experience multiple adverse events. If oncology nurses could identify patients likely to have pronounced chemotherapy-related adverse events, tailored supportive care could be matched to these patients' symptom burdens.<h4>Objective</h4>The aim of this study was to identify symptom profiles in children and adolescents before and after chemotherapy, and the sociodemographic and psychological factors associated with profile classification and change.<h4>Methods</h4>Participants ranging from 7 to 18 years (n = 436) completed 6 Patient-Reported Outcomes Measurement Information System pediatric symptom measures within 72 hours preceding (T1) and 1 to 2 weeks afte2023-01-01T00:00:00Z2023 Mar-Apr 012026-04-17T19:03:01.096Z2025-04-06T12:27:51.556ZS-EPMC99410763581603210.1097/NCC.000000000000112210.1097/ncc.0000000000001122