biostudies-literatureHengist AKnowledge Centre Sugar &amp; NutritionMedical Research CouncilRank Prize Funds921-940https://www.ebi.ac.uk/biostudies/studies/S-EPMC9941259biostudies-literatureUnknown62(2)<h4>Purpose</h4>To determine the effects of dietary sugar or carbohydrate restriction on physical activity energy expenditure, energy intake, and physiological outcomes across 24 h.<h4>Methods</h4>In a randomized, open-label crossover design, twenty-five healthy men (n = 10) and women (n = 15) consumed three diets over a 24-h period: moderate carbohydrate and sugar content (MODSUG = 50% carbohydrate [20% sugars], 15% protein, 35% fat); low sugar content (LOWSUG = 50% carbohydrate [< 5% sugars], 15% protein, 35% fat); and low carbohydrate content (LOWCHO = 8% carbohydrate [< 5% sugars], 15% protein, 77% fat). Postprandial metabolic responses to a prescribed breakfast (20% EI) were monitored under laboratory conditions before an ad libitum test lunch, with subsequent diet and physical activiEuropean journal of nutritionRestricting sugar or carbohydrate intake does not impact physical activity level or energy intake over 24 h despite changes in substrate use: a randomised crossover study in healthy men and women.PMC9941259MR/P002927/1Brunstrom JMHengist ADavies RGRogers PJBetts JAWalhin JPGonzalez JTvan Loon LJCThompson DKoumanov FfalseRestricting sugar or carbohydrate intake does not impact physical activity level or energy intake over 24 h despite changes in substrate use: a randomised crossover study in healthy men and women.<h4>Purpose</h4>To determine the effects of dietary sugar or carbohydrate restriction on physical activity energy expenditure, energy intake, and physiological outcomes across 24 h.<h4>Methods</h4>In a randomized, open-label crossover design, twenty-five healthy men (n = 10) and women (n = 15) consumed three diets over a 24-h period: moderate carbohydrate and sugar content (MODSUG = 50% carbohydrate [20% sugars], 15% protein, 35% fat); low sugar content (LOWSUG = 50% carbohydrate [< 5% sugars], 15% protein, 35% fat); and low carbohydrate content (LOWCHO = 8% carbohydrate [< 5% sugars], 15% protein, 77% fat). Postprandial metabolic responses to a prescribed breakfast (20% EI) were monitored under laboratory conditions before an ad libitum test lunch, with subsequent diet and physical activi2023-01-01T00:00:00Z2023 Mar2026-05-28T20:10:49.074Z2025-02-19T04:46:16.081ZS-EPMC99412593632686310.1007/s00394-022-03048-x