{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["43(3)"],"submitter":["Heeman F"],"pubmed_abstract":["Alzheimer's disease is characterized by regional reductions in cerebral blood flow (CBF). Although the gold standard for measuring CBF is [<sup>15</sup>O]H<sub>2</sub>O PET, proxies of relative CBF, derived from the early distribution phase of amyloid and tau tracers, have gained attention. The present study assessed precision of [<sup>15</sup>O]H<sub>2</sub>O derived relative and absolute CBF, and compared precision of these measures with that of (relative) CBF proxies. Dynamic [<sup>15</sup>O]H<sub>2</sub>O, [<sup>18</sup>F]florbetapir and [<sup>18</sup>F]flortaucipir PET test-retest (TrT) datasets with eleven, nine and fourteen subjects, respectively, were included. Analyses were performed using an arterial input model and/or a simplified reference tissue model, depending on the data av"],"journal":["Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism"],"pagination":["369-378"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9941867"],"repository":["biostudies-literature"],"pubmed_title":["Precision estimates of relative and absolute cerebral blood flow in Alzheimer's disease and cognitively normal individuals."],"pmcid":["PMC9941867"],"pubmed_authors":["Visser D","van der Flier WM","Verfaillie S","Lammertsma AA","Golla SS","Heeman F","Timmers T","Pijnenburg YA","van Berckel BN","Yaqub M","Boellaard R"],"additional_accession":[]},"is_claimable":false,"name":"Precision estimates of relative and absolute cerebral blood flow in Alzheimer's disease and cognitively normal individuals.","description":"Alzheimer's disease is characterized by regional reductions in cerebral blood flow (CBF). Although the gold standard for measuring CBF is [<sup>15</sup>O]H<sub>2</sub>O PET, proxies of relative CBF, derived from the early distribution phase of amyloid and tau tracers, have gained attention. The present study assessed precision of [<sup>15</sup>O]H<sub>2</sub>O derived relative and absolute CBF, and compared precision of these measures with that of (relative) CBF proxies. Dynamic [<sup>15</sup>O]H<sub>2</sub>O, [<sup>18</sup>F]florbetapir and [<sup>18</sup>F]flortaucipir PET test-retest (TrT) datasets with eleven, nine and fourteen subjects, respectively, were included. Analyses were performed using an arterial input model and/or a simplified reference tissue model, depending on the data av","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-05T11:31:51.235Z","creation":"2025-02-18T22:53:19.036Z"},"accession":"S-EPMC9941867","cross_references":{"pubmed":["36271598"],"doi":["10.1177/0271678X221135270"]}}