{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chhoda A"],"funding":["NCATS NIH HHS","NCI NIH HHS","NIH HHS"],"pagination":["28"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9942382"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Background</h4>Intraductal papillary mucinous neoplasms (IPMNs), a type of cystic pancreatic cancer (PC) precursors, are increasingly identified on cross-sectional imaging and present a significant diagnostic challenge. While surgical resection of IPMN-related advanced neoplasia, i.e., IPMN-related high-grade dysplasia or PC, is an essential early PC detection strategy, resection is not recommended for IPMN-low-grade dysplasia (LGD) due to minimal risk of carcinogenesis, and significant procedural risks. Based on their promising results in prior validation studies targeting early detection of classical PC, DNA hypermethylation-based markers may serve as a biomarker for malignant risk stratification of IPMNs. This study investigates our DNA methylation-based PC biomarker panel (ADAMTS1,"],"journal":["Clinical epigenetics"],"pubmed_title":["Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms."],"pmcid":["PMC9942382"],"funding_grant_id":["P30 CA008748","R01 CA185357","UL1 TR001863","P30CA016359"],"pubmed_authors":["Tan WY","Kunstman JW","Sailo B","Iacobuzio-Donahue C","Khatri R","Wolfgang CL","Ruzgar N","Tang H","Ying L","Salem RR","Mane S","Sharma A","Chhoda A","Narayanan A","De Kumar B","Wood LD","Farrell JJ","Ahuja N"],"additional_accession":[]},"is_claimable":false,"name":"Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms.","description":"<h4>Background</h4>Intraductal papillary mucinous neoplasms (IPMNs), a type of cystic pancreatic cancer (PC) precursors, are increasingly identified on cross-sectional imaging and present a significant diagnostic challenge. While surgical resection of IPMN-related advanced neoplasia, i.e., IPMN-related high-grade dysplasia or PC, is an essential early PC detection strategy, resection is not recommended for IPMN-low-grade dysplasia (LGD) due to minimal risk of carcinogenesis, and significant procedural risks. Based on their promising results in prior validation studies targeting early detection of classical PC, DNA hypermethylation-based markers may serve as a biomarker for malignant risk stratification of IPMNs. This study investigates our DNA methylation-based PC biomarker panel (ADAMTS1,","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-22T08:52:02.516Z","creation":"2025-02-18T22:55:02.029Z"},"accession":"S-EPMC9942382","cross_references":{"pubmed":["36803844"],"doi":["10.1186/s13148-023-01429-5"]}}