biostudies-literatureChhoda ANCATS NIH HHSNCI NIH HHSNIH HHS28https://www.ebi.ac.uk/biostudies/studies/S-EPMC9942382biostudies-literatureUnknown15(1)<h4>Background</h4>Intraductal papillary mucinous neoplasms (IPMNs), a type of cystic pancreatic cancer (PC) precursors, are increasingly identified on cross-sectional imaging and present a significant diagnostic challenge. While surgical resection of IPMN-related advanced neoplasia, i.e., IPMN-related high-grade dysplasia or PC, is an essential early PC detection strategy, resection is not recommended for IPMN-low-grade dysplasia (LGD) due to minimal risk of carcinogenesis, and significant procedural risks. Based on their promising results in prior validation studies targeting early detection of classical PC, DNA hypermethylation-based markers may serve as a biomarker for malignant risk stratification of IPMNs. This study investigates our DNA methylation-based PC biomarker panel (ADAMTS1,Clinical epigeneticsUtility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms.PMC9942382P30 CA008748R01 CA185357UL1 TR001863P30CA016359Tan WYKunstman JWSailo BIacobuzio-Donahue CKhatri RWolfgang CLRuzgar NTang HYing LSalem RRMane SSharma AChhoda ANarayanan ADe Kumar BWood LDFarrell JJAhuja NfalseUtility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms.<h4>Background</h4>Intraductal papillary mucinous neoplasms (IPMNs), a type of cystic pancreatic cancer (PC) precursors, are increasingly identified on cross-sectional imaging and present a significant diagnostic challenge. While surgical resection of IPMN-related advanced neoplasia, i.e., IPMN-related high-grade dysplasia or PC, is an essential early PC detection strategy, resection is not recommended for IPMN-low-grade dysplasia (LGD) due to minimal risk of carcinogenesis, and significant procedural risks. Based on their promising results in prior validation studies targeting early detection of classical PC, DNA hypermethylation-based markers may serve as a biomarker for malignant risk stratification of IPMNs. This study investigates our DNA methylation-based PC biomarker panel (ADAMTS1,2023-01-01T00:00:00Z2023 Feb2025-04-22T08:52:02.516Z2025-02-18T22:55:02.029ZS-EPMC99423823680384410.1186/s13148-023-01429-5