biostudies-literaturePeng BInternational Science and Technology Cooperation ProgrammeNational Key Research and Development Program of China62https://www.ebi.ac.uk/biostudies/studies/S-EPMC9942410biostudies-literatureUnknown23(1)<h4>Background</h4>Systemic sclerosis (SSc; also known as "scleroderma") is an autoimmune disorder characterized by extensive fibrosis, vascular changes, and immunologic dysregulation. Baicalein (phenolic flavonoid derived from Scutellaria baicalensis Georgi) has been used to treat the pathological processes of various fibrotic and inflammatory diseases. In this study, we investigated the effect of baicalein on the major pathologic characteristics of SSc: fibrosis, B-cell abnormalities, and inflammation.<h4>Methods</h4>The effect of baicalein on collagen accumulation and expression of fibrogenic markers in human dermal fibroblasts were analyzed. SSc mice were produced by injecting bleomycin and treated with baicalein (25, 50, or 100 mg/kg). The antifibrotic features of baicalein and its meBMC complementary medicine and therapiesBaicalein alleviates fibrosis and inflammation in systemic sclerosis by regulating B-cell abnormalities.PMC99424102013DFG310802018YFC1708100, 2018YFC1708105Song LZhang GLi HLi JPeng BGao YChen YLian DHu QHou HHe RChen TfalseBaicalein alleviates fibrosis and inflammation in systemic sclerosis by regulating B-cell abnormalities.<h4>Background</h4>Systemic sclerosis (SSc; also known as "scleroderma") is an autoimmune disorder characterized by extensive fibrosis, vascular changes, and immunologic dysregulation. Baicalein (phenolic flavonoid derived from Scutellaria baicalensis Georgi) has been used to treat the pathological processes of various fibrotic and inflammatory diseases. In this study, we investigated the effect of baicalein on the major pathologic characteristics of SSc: fibrosis, B-cell abnormalities, and inflammation.<h4>Methods</h4>The effect of baicalein on collagen accumulation and expression of fibrogenic markers in human dermal fibroblasts were analyzed. SSc mice were produced by injecting bleomycin and treated with baicalein (25, 50, or 100 mg/kg). The antifibrotic features of baicalein and its me2023-01-01T00:00:00Z2023 Feb2025-04-18T14:12:54.244Z2025-02-19T02:55:41.643ZS-EPMC99424103681008110.1186/s12906-023-03885-1