{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu W"],"funding":["NIBIB NIH HHS","NIAID NIH HHS","NCI NIH HHS"],"pagination":["111987"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9943022"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(1)"],"pubmed_abstract":["T cell activation, proliferation, function, and differentiation are tightly linked to proper metabolic reprogramming and regulation. By using [U-<sup>13</sup>C]glucose tracing, we reveal a critical role for GOT1 in promoting CD8<sup>+</sup> T cell effector differentiation and function. Mechanistically, GOT1 enhances proliferation by maintaining intracellular redox balance and serine-mediated purine nucleotide biosynthesis. Further, GOT1 promotes the glycolytic programming and cytotoxic function of cytotoxic T lymphocytes via posttranslational regulation of HIF protein, potentially by regulating the levels of α-ketoglutarate. Conversely, genetic deletion of GOT1 promotes the generation of memory CD8<sup>+</sup> T cells."],"journal":["Cell reports"],"pubmed_title":["GOT1 regulates CD8<sup>+</sup> effector and memory T cell generation."],"pmcid":["PMC9943022"],"funding_grant_id":["R01 CA229451","R01 AI155602","P41 EB028239","R01 AI077610","R01 CA226765"],"pubmed_authors":["Zhao L","Wen J","Patel CH","Sun IH","Helms RS","Powell JD","Oh MH","Xu W","Sun IM"],"additional_accession":[]},"is_claimable":false,"name":"GOT1 regulates CD8<sup>+</sup> effector and memory T cell generation.","description":"T cell activation, proliferation, function, and differentiation are tightly linked to proper metabolic reprogramming and regulation. By using [U-<sup>13</sup>C]glucose tracing, we reveal a critical role for GOT1 in promoting CD8<sup>+</sup> T cell effector differentiation and function. Mechanistically, GOT1 enhances proliferation by maintaining intracellular redox balance and serine-mediated purine nucleotide biosynthesis. Further, GOT1 promotes the glycolytic programming and cytotoxic function of cytotoxic T lymphocytes via posttranslational regulation of HIF protein, potentially by regulating the levels of α-ketoglutarate. Conversely, genetic deletion of GOT1 promotes the generation of memory CD8<sup>+</sup> T cells.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-22T09:57:41.308Z","creation":"2025-02-18T22:57:31.034Z"},"accession":"S-EPMC9943022","cross_references":{"pubmed":["36640309"],"doi":["10.1016/j.celrep.2022.111987"]}}