{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["135(21)"],"submitter":["Tang X"],"pubmed_abstract":["<h4>Background</h4>Abnormal lipids are strong predictors of cardiovascular disease in type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). However, the potential associations of insulin resistance (IR) and beta-cell function (BCF) with abnormal lipids in newly diagnosed T1DM or T2DM patients are not fully understood.<h4>Methods</h4>A cross-sectional survey of 15,928 participants was conducted. Homeostasis model assessment and postprandial C-peptide levels were used to estimate IR and BCF. A restricted cubic spline (RCS) nested in binary logistic regression was used to examine the associations of IR and BCF with abnormal lipids.<h4>Results</h4>High triglyceride (TG), low high-density lipoprotein cholesterol, and high low-density lipoprotein cholesterol (LDL-C) accounted for 49.7%, 47.8%, and 59.2% of the participants, respectively. In multivariable analysis, high IR was associated with an increased risk of high TGs ( P for trend <0.001) in T1DM and is associated with an elevated risk of high TG and low HDL-C (all P for trend <0.01) in T2DM. Low BCF was not associated with risks of dyslipidemia in patients with T1DM or T2DM after adjustment for potential confounders.<h4>Conclusion</h4>High IR had different associations with the risk of dyslipidemia in newly diagnosed T1DM and T2DM patients, suggesting that early treatment that improves IR may benefit abnormal lipid metabolism."],"journal":["Chinese medical journal"],"pagination":["2554-2562"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9944004"],"repository":["biostudies-literature"],"pubmed_title":["Associations of insulin resistance and beta-cell function with abnormal lipid profile in newly diagnosed diabetes."],"pmcid":["PMC9944004"],"pubmed_authors":["Yang X","Li X","Huang G","Jiang H","Yan X","Zhou H","Su H","Niu X","Tang X","Zhou Z"],"additional_accession":[]},"is_claimable":false,"name":"Associations of insulin resistance and beta-cell function with abnormal lipid profile in newly diagnosed diabetes.","description":"<h4>Background</h4>Abnormal lipids are strong predictors of cardiovascular disease in type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). However, the potential associations of insulin resistance (IR) and beta-cell function (BCF) with abnormal lipids in newly diagnosed T1DM or T2DM patients are not fully understood.<h4>Methods</h4>A cross-sectional survey of 15,928 participants was conducted. Homeostasis model assessment and postprandial C-peptide levels were used to estimate IR and BCF. A restricted cubic spline (RCS) nested in binary logistic regression was used to examine the associations of IR and BCF with abnormal lipids.<h4>Results</h4>High triglyceride (TG), low high-density lipoprotein cholesterol, and high low-density lipoprotein cholesterol (LDL-C) accounted for 49.7%, 47.8%, and 59.2% of the participants, respectively. In multivariable analysis, high IR was associated with an increased risk of high TGs ( P for trend <0.001) in T1DM and is associated with an elevated risk of high TG and low HDL-C (all P for trend <0.01) in T2DM. Low BCF was not associated with risks of dyslipidemia in patients with T1DM or T2DM after adjustment for potential confounders.<h4>Conclusion</h4>High IR had different associations with the risk of dyslipidemia in newly diagnosed T1DM and T2DM patients, suggesting that early treatment that improves IR may benefit abnormal lipid metabolism.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T12:44:35.101Z","creation":"2025-04-04T12:44:35.101Z"},"accession":"S-EPMC9944004","cross_references":{"pubmed":["35245924"],"doi":["10.1097/CM9.0000000000002075"]}}