{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Knizner KT"],"funding":["AbbVie","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["328-334"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9944060"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(2)"],"pubmed_abstract":["Infrared matrix-assisted laser desorption ionization (IR-MALDESI) is a hybrid mass spectrometry ionization source that combines the benefits of electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) making it a great analytical tool for high-throughput screening (HTS) analyses. IR-MALDESI is coupled to an Orbitrap Exploris 240 mass spectrometer that utilizes a bent quadrupole (C-trap) to inject accumulated ions into the high-field Orbitrap mass analyzer. Here, we present a study on the optimized C-trap timing for HTS analyses by IR-MALDESI mass spectrometry. The timing between initial ion generation and the C-trap opening time was optimized to reduce unnecessary ambient ion accumulation in the mass spectrometer. The time in which the C-trap was held open, the"],"journal":["Journal of the American Society for Mass Spectrometry"],"pubmed_title":["Optimized C-Trap Timing of an Orbitrap 240 Mass Spectrometer for High-Throughput Screening and Native MS by IR-MALDESI."],"pmcid":["PMC9944060"],"funding_grant_id":["R01 GM087964","R01GM087964"],"pubmed_authors":["Bagley MC","Hauschild JP","Williams JD","Muddiman DC","Elsen NL","Knizner KT","Pu F","Garrard KP"],"additional_accession":[]},"is_claimable":false,"name":"Optimized C-Trap Timing of an Orbitrap 240 Mass Spectrometer for High-Throughput Screening and Native MS by IR-MALDESI.","description":"Infrared matrix-assisted laser desorption ionization (IR-MALDESI) is a hybrid mass spectrometry ionization source that combines the benefits of electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) making it a great analytical tool for high-throughput screening (HTS) analyses. IR-MALDESI is coupled to an Orbitrap Exploris 240 mass spectrometer that utilizes a bent quadrupole (C-trap) to inject accumulated ions into the high-field Orbitrap mass analyzer. Here, we present a study on the optimized C-trap timing for HTS analyses by IR-MALDESI mass spectrometry. The timing between initial ion generation and the C-trap opening time was optimized to reduce unnecessary ambient ion accumulation in the mass spectrometer. The time in which the C-trap was held open, the","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-04T00:02:55.72Z","creation":"2025-04-04T00:02:55.72Z"},"accession":"S-EPMC9944060","cross_references":{"pubmed":["35073091"],"doi":["10.1021/jasms.1c00319"]}}