{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Amado CA"],"pubmed_abstract":["<h4>Background</h4>MOTS-c and Romo1 are mitochondrial peptides that are modulated by oxidative stress. No previous studies have explored circulating levels of MOTS-c in patients with chronic obstructive pulmonary disease (COPD).<h4>Methods</h4>We enrolled 142 patients with stable COPD and 47 smokers with normal lung function in an observational cross-sectional study. We assessed serum levels of both MOTS-c and Romo1 and associated these findings with clinical characteristics of COPD.<h4>Results</h4>Compared with smokers with normal lung function, patients with COPD had lower levels of MOTS-c (<i>p</i> = 0.02) and higher levels of Romo1 (<i>p</i> = 0.01). A multivariate logistic regression analysis revealed that above-median MOTS-c levels were positively associated with Romo1 levels (OR 1.0"],"journal":["Frontiers in medicine"],"pagination":["1100211"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9944395"],"repository":["biostudies-literature"],"pubmed_title":["Circulating levels of mitochondrial oxidative stress-related peptides MOTS-c and Romo1 in stable COPD: A cross-sectional study."],"pmcid":["PMC9944395"],"pubmed_authors":["Ferrer-Pargada D","Lavin BA","Guerra AR","Martin F","Garcia-Unzueta M","Amado CA","Martin-Audera P","Aguero J","Boucle D","Casanova C","Berja A"],"additional_accession":[]},"is_claimable":false,"name":"Circulating levels of mitochondrial oxidative stress-related peptides MOTS-c and Romo1 in stable COPD: A cross-sectional study.","description":"<h4>Background</h4>MOTS-c and Romo1 are mitochondrial peptides that are modulated by oxidative stress. No previous studies have explored circulating levels of MOTS-c in patients with chronic obstructive pulmonary disease (COPD).<h4>Methods</h4>We enrolled 142 patients with stable COPD and 47 smokers with normal lung function in an observational cross-sectional study. We assessed serum levels of both MOTS-c and Romo1 and associated these findings with clinical characteristics of COPD.<h4>Results</h4>Compared with smokers with normal lung function, patients with COPD had lower levels of MOTS-c (<i>p</i> = 0.02) and higher levels of Romo1 (<i>p</i> = 0.01). A multivariate logistic regression analysis revealed that above-median MOTS-c levels were positively associated with Romo1 levels (OR 1.0","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T14:17:45.964Z","creation":"2025-02-19T02:24:00.205Z"},"accession":"S-EPMC9944395","cross_references":{"pubmed":["36844198"],"doi":["10.3389/fmed.2023.1100211"]}}