biostudies-literatureUnknown10Amado CA<h4>Background</h4>MOTS-c and Romo1 are mitochondrial peptides that are modulated by oxidative stress. No previous studies have explored circulating levels of MOTS-c in patients with chronic obstructive pulmonary disease (COPD).<h4>Methods</h4>We enrolled 142 patients with stable COPD and 47 smokers with normal lung function in an observational cross-sectional study. We assessed serum levels of both MOTS-c and Romo1 and associated these findings with clinical characteristics of COPD.<h4>Results</h4>Compared with smokers with normal lung function, patients with COPD had lower levels of MOTS-c (<i>p</i> = 0.02) and higher levels of Romo1 (<i>p</i> = 0.01). A multivariate logistic regression analysis revealed that above-median MOTS-c levels were positively associated with Romo1 levels (OR 1.0Frontiers in medicine1100211https://www.ebi.ac.uk/biostudies/studies/S-EPMC9944395biostudies-literatureCirculating levels of mitochondrial oxidative stress-related peptides MOTS-c and Romo1 in stable COPD: A cross-sectional study.PMC9944395Ferrer-Pargada DLavin BAGuerra ARMartin FGarcia-Unzueta MAmado CAMartin-Audera PAguero JBoucle DCasanova CBerja AfalseCirculating levels of mitochondrial oxidative stress-related peptides MOTS-c and Romo1 in stable COPD: A cross-sectional study.<h4>Background</h4>MOTS-c and Romo1 are mitochondrial peptides that are modulated by oxidative stress. No previous studies have explored circulating levels of MOTS-c in patients with chronic obstructive pulmonary disease (COPD).<h4>Methods</h4>We enrolled 142 patients with stable COPD and 47 smokers with normal lung function in an observational cross-sectional study. We assessed serum levels of both MOTS-c and Romo1 and associated these findings with clinical characteristics of COPD.<h4>Results</h4>Compared with smokers with normal lung function, patients with COPD had lower levels of MOTS-c (<i>p</i> = 0.02) and higher levels of Romo1 (<i>p</i> = 0.01). A multivariate logistic regression analysis revealed that above-median MOTS-c levels were positively associated with Romo1 levels (OR 1.02023-01-01T00:00:00Z20232025-04-04T14:17:45.964Z2025-02-19T02:24:00.205ZS-EPMC99443953684419810.3389/fmed.2023.1100211