{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["327"],"submitter":["Castillo G"],"pubmed_abstract":["Human coronavirus NL63 (HCoV-NL63) is spread globally, causing upper and lower respiratory tract infections mainly in young children. HCoV-NL63 shares a host receptor (ACE2) with severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 but, unlike them, HCoV-NL63 primarily develops into self-limiting mild to moderate respiratory disease. Although with different efficiency, both HCoV-NL63 and SARS-like CoVs infect ciliated respiratory cells using ACE2 as receptor for binding and cell entry. Working with SARS-like CoVs require access to BSL-3 facilities, while HCoV-NL63 research can be performed at BSL-2 laboratories. Thus, HCoV-NL63 could be used as a safer surrogate for comparative studies on receptor dynamics, infectivity and virus replication, disease mechanism, and potent"],"journal":["Virus research"],"pagination":["199078"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9944649"],"repository":["biostudies-literature"],"pubmed_title":["Molecular mechanisms of human coronavirus NL63 infection and replication."],"pmcid":["PMC9944649"],"pubmed_authors":["Breuer M","Singh P","Nelli RK","Gimenez-Lirola LG","Mora-Diaz JC","Castillo G"],"additional_accession":[]},"is_claimable":false,"name":"Molecular mechanisms of human coronavirus NL63 infection and replication.","description":"Human coronavirus NL63 (HCoV-NL63) is spread globally, causing upper and lower respiratory tract infections mainly in young children. HCoV-NL63 shares a host receptor (ACE2) with severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 but, unlike them, HCoV-NL63 primarily develops into self-limiting mild to moderate respiratory disease. Although with different efficiency, both HCoV-NL63 and SARS-like CoVs infect ciliated respiratory cells using ACE2 as receptor for binding and cell entry. Working with SARS-like CoVs require access to BSL-3 facilities, while HCoV-NL63 research can be performed at BSL-2 laboratories. Thus, HCoV-NL63 could be used as a safer surrogate for comparative studies on receptor dynamics, infectivity and virus replication, disease mechanism, and potent","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-04T14:17:06.237Z","creation":"2025-02-19T02:23:52.358Z"},"accession":"S-EPMC9944649","cross_references":{"pubmed":["36813239"],"doi":["10.1016/j.virusres.2023.199078"]}}